酚妥拉明联合重组人脑利钠肽治疗急性左心衰竭患者的疗效及对GRP78、PTX3和GDF-15的影响

远洋; 孟宇; 韩拓; 张京苗; 融劭民

doi:10.14009/j.issn.1672-2124.2023.01.012

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酚妥拉明联合重组人脑利钠肽治疗急性左心衰竭患者的疗效及对GRP78、PTX3和GDF-15的影响

论著 | 更新时间：2023-04-14

- 酚妥拉明联合重组人脑利钠肽治疗急性左心衰竭患者的疗效及对GRP78、PTX3和GDF-15的影响
- Efficacy of Phentolamine Combined with Recombinant Human Brain Natriuretic Peptide in the Treatment of Patients with Acute Left Heart Failure and Its Effect on GRP78,PTX3 and GDF-15
- 中国医院用药评价与分析 2023年第1期页码：58-61
- 作者机构：
  
  1. 石家庄市急救中心第五中心站
  2. 石家庄市急救中心急救医学部
  3. 中国人民解放军陆军第八十二集团军医院急诊科
- 作者简介：
- 基金信息：
  
  河北省医学科学研究课题计划（No.20201607）
- DOI：10.14009/j.issn.1672-2124.2023.01.012
  中图分类号： R541.6
- 纸质出版日期：2023，
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远洋, 孟宇, 韩拓, 等. 酚妥拉明联合重组人脑利钠肽治疗急性左心衰竭患者的疗效及对GRP78、PTX3和GDF-15的影响[J]. 中国医院用药评价与分析, 2023,(1):58-61.

YUAN Yang, MENG Yu, HAN Tuo, et al. Efficacy of Phentolamine Combined with Recombinant Human Brain Natriuretic Peptide in the Treatment of Patients with Acute Left Heart Failure and Its Effect on GRP78,PTX3 and GDF-15[J]. 2023,(1):58-61.
远洋, 孟宇, 韩拓, 等. 酚妥拉明联合重组人脑利钠肽治疗急性左心衰竭患者的疗效及对GRP78、PTX3和GDF-15的影响[J]. 中国医院用药评价与分析, 2023,(1):58-61. DOI： 10.14009/j.issn.1672-2124.2023.01.012.

YUAN Yang, MENG Yu, HAN Tuo, et al. Efficacy of Phentolamine Combined with Recombinant Human Brain Natriuretic Peptide in the Treatment of Patients with Acute Left Heart Failure and Its Effect on GRP78,PTX3 and GDF-15[J]. 2023,(1):58-61. DOI： 10.14009/j.issn.1672-2124.2023.01.012.

摘要

目的：探讨酚妥拉明联合重组人脑利钠肽治疗急性左心衰竭患者的效果及对葡萄糖调节蛋白78（GRP78）、五聚素3（PTX3）和生长分化因子15（GDF-15）的影响。方法：采用随机数字表法将2021年石家庄市急救中心第五中心站收治的急性左心衰竭患者130例分为对照组（n=65）与研究组（n=65）。对照组患者在常规治疗基础上予以酚妥拉明治疗，研究组患者在对照组的基础上加用重组人脑利钠肽治疗。比较两组患者治疗前后的心功能指标，GRP78、PTX3和GDF-15水平；观察两组患者的临床疗效和治疗期间的不良反应。结果：研究组患者治疗总有效率为96.92%（63/65）

显著高于对照组的87.69%（57/65）

差异有统计学意义（P＜0.05）。两组患者治疗后左心室射血分数、心脏指数和每搏输出量显著高于治疗前，且研究组患者显著高于对照组，差异均有统计学意义（P＜0.05）。两组患者治疗后左心室舒张末期内径，GRP78、PTX3和GDF-15水平显著低于治疗前，且研究组患者显著低于对照组，差异均有统计学意义（P＜0.05）。对照组、研究组患者的不良反应发生率比较[3.08%（2/65）vs. 6.15%（4/65）]

差异无统计学意义（P＞0.05）。结论：酚妥拉明联合重组人脑利钠肽治疗急性左心衰竭的疗效和安全性均较高，可有效改善患者的心功能指标，降低GRP78、PTX3和GDF-15水平。

Abstract

OBJECTIVE: To probe into the efficacy of phentolamine combined with recombinant human brain natriuretic peptide in the treatment of patients with acute left heart failure and its effect on glucose-regulated protein 78（GRP78）

Pentraxin 3（PTX3） and growth differentiation factor-15（GDF-15）. METHODS: Totally 130 patients with acute left heart failure admitted into the Fifth Center Station

the Emergency Center of Shijiazhuang in 2021 were divided into control group（n=65） and research group（n=65） via random number table method. The control group was given phentolamine based on conventional therapy

while the research group was given recombinant human brain natriuretic peptide based ont he control group. The cardiac function indicators

GRP78

PTX3 and GDF-15 levels were compared between two groups before and after treatment

the clinical efficacy and adverse drug reactions during treatment of the two groups were observed. RESULTS: The total effective rate of research group was 96.92%（63/65）

which was significantly higher than that of the control group（87.69%

57/65）

with statistically significant difference（P<0.05）. The left ventricular ejection fraction

cardiac index and stroke volume of both groups after treatment were significantly higher than those before treatment

and those of the research group were significantly higher than the control group

with statistically significant differences（P<0.05）. The left ventricular end-diastolic dimension

GRP78

PTX3 and GDF-15 levels of both groups after treatment were significantly lower than those before treatment

and those of the research group were significantly lower than the control group

with statistically significant differences（P<0.05）. The difference in the incidence of adverse drug reactions between control group and research group [3.08%（2/65） vs. 6.15%（4/65）] was not statistically significant（P>0.05）. CONCLUSIONS: The efficacy and safety of phentolamine combined with recombinant human brain natriuretic peptide in the treatment of patients with acute left heart failure is remarkable

which can effectively improve patients’ cardiac function indicators

reduce the GRP78

PTX3 and GDF-15 levels.

关键词

酚妥拉明重组人脑利钠肽急性左心衰竭心功能指标葡萄糖调节蛋白78五聚素3生长分化因子15

Keywords

PhentolamineRecombinant human brain natriuretic peptideAcute left heart failureCardiac function indicatorsGlucose regulatory protein 78Pentraxin 3Growth differentiation factor-15

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