OBJECTIVE: To probe into the effects of Huangqi Guizhi Wuwu decoction on heart rate recovery from bradyarrhythmia

serum fatty acid binding protein levels and plasma Ang Ⅱ

Adropin and galectin（Gal） 3. METHODS: A total of 120 patients with bradyarrhythmias admitted into the hospital from Apr. 2020 to Apr. 2021 were extracted to be divided into the control group and the observation group via the random number table method

with 60 cases in each group. The control group was treated with routine treatment

while the observation group received Huangqi Guizhi Wuwu decoction based on the control group. The levels of Gal-3

vasoactive intestinal peptide（VIP）

nitric oxide（NO） and Ang Ⅱ

Adropin

growth differentiation factor（GDF）-15

creatine kinase isoenzyme（CK-MB）

heart-type fatty acid binding protein（H-FABP）

endogenous nociceptin/orphanin FQ（N/OFQ）

left ventricular ejection fraction（LVEF）

heart rate（HR）

root mean square of the difference between successive NN intervals（RMSSD）

every 5 min NN standard deviation of mean interval（SDANN） and total NN interval（SDNN） before and after treatment in two groups were detected. Clinical efficacy of two groups were compared. RESULTS: After treatment

the level of Ang Ⅱ of the observation group was lower than that of the control group

the levels of VIP

Adropin and NO were higher than those of the control group

the levels of Gal-3

GDF-15 was lower than that of the control group

the levels of H-FABP

CK-MB and N/OFQ were lower than those of the control group

the levels of LVEF and HR were higher than those of the control group

the levels of RMSSD and SDANN were lower than those in the control group

the level of SDNN was higher than that of the control group

with statistically significant differences（P<0.05）. The total effective rate of the observation group was 96.67%（58/60）

higher than 83.33%（50/60） of the control group

the difference was statistically significant（P<0.05）. CONCLUSIONS: Huangqi Guizhi Wuwu decoction in the treatment of patients with bradyarrhythmias can improve vascular endothelial function

inhibit inflammation

reduce myocardial damage

improve heart rate

heart rate variability and cardiac function

and improve the clinical efficacy.