OBJECTIVE: To observe the clinical efficacy of Shugan Wenyang powder in the treatment of erectile dysfunction in patients with depression and erectile dysfunction（ED）

and to explore its mechanism through NO-cGMP signal pathway. METHODS: One hundred patients with depression and ED in the hospital were randomly divided into the observation group and control group

with 50 cases in each group. The control group was treated with Tadalafil tablets

while the observation group received Shugan Wenyang powder on the basis of western medicine. Both groups were treated for 4 weeks. The clinical efficacy of ED treatment in two groups was evaluated. The depressive symptoms of two groups were evaluated by Hamilton Depression Scale 17（HAMD-17） and self rating Depression Scale（SDS）

the erectile function of two groups was evaluated by international erectile function index（IIEF-5）

and the adverse drug reactions and quality of life of two groups were evaluated by antidepressant adverse reaction scale（SERS） and World Health Organization Quality of life scale（WHOQOL-BREF）. The expression levels of nNOS

eNOS

NO and cGMP in plasma of corpus cavernosum of penis were detected by enzyme-linked immunosorbent assay. RESULTS: After 4 weeks of treatment

the total effective rate of ED in the observation group was 92.0%（46/50）

significantly higher than 76.0%（38/50） in the control group

the difference was statistically significant（P<0.05）. After 4 weeks of treatment

the HAMD-17

SDS and SERS scores of the observation group were significantly lower than those of the control group

and the IIEF-5 and WHOQOL-BREF scores were significantly higher than those of the control group; the levels of nNOS

eNOS

NO and cGMP in plasma of corpus cavernosum in the observation group were significantly higher than those in the control group

the differences were statistically significant（P<0.05）. CONCLUSIONS: The efficacy of Shugan Wenyang powder in the treatment of erectile dysfunction in patients with depression and ED is significant

which can improve the depressive symptoms

erectile function and the quality of life

and effectively reduce the adverse drug reactions. Its mechanism may be related to regulating NO-cGMP signal pathway and promoting the relaxation of penile spongy body.