OBJECTIVE: To probe into the application effect of the Internet of Things health management model in elderly patients with multiple medications. METHODS: A total of 134 elderly patients with multiple medications admitted into the hospital from Jan. 2019 to Sept. 2021 were selected and divided into observation and control group via simple randomization method. The control group was given routine management

while the observation group was given IoT health management model. The awareness of drug-related knowledge

medication compliance and burden of medication before and after intervention were compared between two groups

and the medication safety of the two groups after intervention were evaluated. RESULTS: After intervention

the awareness of drug-related knowledge in the observation group was higher than that of the same group before intervention

and higher than that of the control group

with statistically significant differences（P<0.05）; after intervention

the medication compliance of both groups had been increased

and that of the observation group was higher than the control group

with statistically significant differences（P<0.05）; after intervention

scores of the burden of medication in both groups had been decreased

and that of the observation group was lower than the control group

with statistically significant differences（P<0.05）. The incidence of adverse drug reactions of the observation group was 22.39%（15/67）

which was lower than that of the control group（26/67

38.81%）

with statistically significant difference（P<0.05）. CONCLUSIONS: The IoT health management model can effectively improve the awareness of drug-related knowledge and medication compliance of elderly patients with multiple medications

reduce the burden of medication

and improve medication safety.