OBJECTIVE: To probe into the effects of different administration methods of propofol on circulatory function

cerebral state index（CSI） and Th17/Treg level in patients undergoing breast cancer surgery. METHODS: A total of 130 patients undergoing breast cancer surgery in this hospital from Jun. 2019 to Jun. 2021 were prospectively selected and divided into groups A and group B via random number table

with 65 cases in each group. Both groups were given propofol

group A was administrated by closed-loop target-controlled infusion（CLTCI）

and group B was administrated open-loop target-controlled infusion（OLTCI）. The circulatory function [mean arterial pressure（MAP）

heart rate（HR）

respiratory rate（RR）

end-tidal carbon dioxide(P

ET

CO

2

)]

CSI value

postoperative Th17/Treg level

total dosage of propofol

wake-up time

extubation time

pain degree after extubation and incidence of adverse events in the two groups were observed before anesthesia induction（T

0

）

immediately after intubation（T

1

）

immediately after extubation（T

2

） and after extubation. RESULTS:（1） At T

1

T

2

and T

3

the MAP

HR and RR of group A were higher than those of group B

the CSI value and P

ET

CO

2

of group A were lower than those of group B

and the fluctuation range was smaller than that of group B

with statistically significant differences（P

<

0.05）;（2） at 24 h and 72 h after surgery

the Th17 level of group A was higher than that of group B

the Treg level of group A was lower than that of group B

with statistically significant differences（P

<

0.05）;（3） the total dosage of propofol in group A was less than that of group B

the wake-up time and extubation time of group A were shorter than group B

with statistically significant differences（P

<

0.05）;（4） the difference in the incidences of adverse events between group A and group B [3.08%（2/65） vs. 7.69%（5/65）] was not statistically significant（P

>

0.05）. CONCLUSIONS: Propofol administrated by CLTCI is better than administrated by LTCI in terms of circulatory function

CSI and Th17/Treg levels

which can be used as one of the perioperative anesthesia management programs for breast cancer patients.