加味柴胡疏肝散联合穴位敷贴对肝郁气滞型睡眠障碍患者睡眠进程及睡眠结构的影响

张万辉; 袁萍萍; 马艳丽; 赵娜; 窦荣花

doi:10.14009/j.issn.1672-2124.2022.12.009

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加味柴胡疏肝散联合穴位敷贴对肝郁气滞型睡眠障碍患者睡眠进程及睡眠结构的影响

论著 | 更新时间：2023-04-16

- 加味柴胡疏肝散联合穴位敷贴对肝郁气滞型睡眠障碍患者睡眠进程及睡眠结构的影响
- Effect of Modified Chaihu Shugan Powder Combined with Acupoint Application on Sleep Process and Sleep Structure in Patients with Sleep Disorder of Liver-Depression and Qi-Stagnation
- 中国医院用药评价与分析 2022年第12期页码：1468-1471
- 作者机构：
  
  1. 河北省沧州中西医结合医院脑病科
  2. 沧州市中心医院神经内科
- 作者简介：
- 基金信息：
  
  河北省中医药管理局2022年度中医药类科研计划课题（No.2022599）
- DOI：10.14009/j.issn.1672-2124.2022.12.009
  中图分类号： R277.7
- 纸质出版日期：2022，
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张万辉, 袁萍萍, 马艳丽, 等. 加味柴胡疏肝散联合穴位敷贴对肝郁气滞型睡眠障碍患者睡眠进程及睡眠结构的影响[J]. 中国医院用药评价与分析, 2022,(12):1468-1471.

ZHANG Wanhui, YUAN Pingping, MA Yanli, et al. Effect of Modified Chaihu Shugan Powder Combined with Acupoint Application on Sleep Process and Sleep Structure in Patients with Sleep Disorder of Liver-Depression and Qi-Stagnation[J]. 2022,(12):1468-1471.
张万辉, 袁萍萍, 马艳丽, 等. 加味柴胡疏肝散联合穴位敷贴对肝郁气滞型睡眠障碍患者睡眠进程及睡眠结构的影响[J]. 中国医院用药评价与分析, 2022,(12):1468-1471. DOI： 10.14009/j.issn.1672-2124.2022.12.009.

ZHANG Wanhui, YUAN Pingping, MA Yanli, et al. Effect of Modified Chaihu Shugan Powder Combined with Acupoint Application on Sleep Process and Sleep Structure in Patients with Sleep Disorder of Liver-Depression and Qi-Stagnation[J]. 2022,(12):1468-1471. DOI： 10.14009/j.issn.1672-2124.2022.12.009.

摘要

目的：探讨加味柴胡疏肝散联合穴位敷贴对肝郁气滞型睡眠障碍患者的睡眠及情志的影响。方法：将2020年6月至2021年6月于河北省沧州中西医结合医院就诊的肝郁气滞型睡眠障碍患者100例随机分为对照组（右佐匹克隆片）及观察组（加味柴胡舒肝散颗粒联合穴位贴敷）

每组50例。观察3个月，比较两组患者的睡眠状况自评量表（SRSS）评分、匹兹堡睡眠质量指数（PSQI）评分、多导睡眠图、汉密尔顿焦虑量表（HAMA）评分和汉密尔顿抑郁量表（HAMD）评分，并分析相关性。结果：观察组患者的总有效率为90.0%（45/50）

明显高于对照组的74.0%（37/50）

差异有统计学意义（P＜0.05）。观察组患者治疗2周后的PSQI评分显著低于对照组（P＜0.01）

治疗4周后的SRSS评分明显低于对照组（P＜0.05）

差异均有统计学意义。与对照组相比，观察组患者的睡眠总时间、快速眼动睡眠潜伏期时间、N2期睡眠时间和N3期睡眠时间显著延长，N3期睡眠比例、睡眠效率显著升高；睡眠潜伏期时间、觉醒时间显著缩短，N1、N2期睡眠比例显著降低，差异均有统计学意义（P＜0.05）。HAMD、HAMA评分与总睡眠时间、N3期睡眠时间呈显著负相关，与PSQI评分呈显著正相关。结论：加味柴胡舒肝散颗粒联合穴位贴敷对肝郁气滞型睡眠障碍患者的主观睡眠质量、客观睡眠结构及睡眠进程的总体改善程度更佳，能缓解患者的焦虑抑郁情绪，提高睡眠质量。睡眠障碍与患者焦虑、抑郁状态具有相关性。

Abstract

OBJECTIVE: To probe into the effects of modified Chaihu Shugan powder combined with acupoint application on sleep and emotions in patients with sleep disorder of liver-depression and qi-stagnation. METHODS: A total of 100 patients with sleep disorder of liver-depression and qi-stagnation admitted into Hebei Cangzhou Hospital of Integrated Traditional Chinese and Western Medicine from Jun. 2020 to Jun. 2021 were selected and randomly divided into control group（dexzopiclone tablets） and observation group（modified Chaihu Shugan powder combined with acupoint application）

with 50 cases in each group and observed for 3 months. Scores of Self Rating Scale of Sleep（SRSS）

Pittsburgh Sleep Quality Index（PSQI）

polysomnogram

Hamilton Anxiety Scale（HAMA） and Hamilton Depression Scale（HAMD） were compared between two groups

and the correlation were analyzed. RESULTS: The total effective rate of the observation group was 90.0%（45/50）

which was significantly higher than that of the control group（74.0%

37/50）

with statistically significant difference（P<0.05）. The PSQI score of the observation group after 2 weeks of treatment were significantly lower than that of the control group（P<0.01）

the SRSS score of the observation group after 4 weeks of treatment were significantly lower than that of the control group（P<0.05）

with statistically significant differences. Compared with the control group

the total sleep time

REM sleep latency

N2 and N3 stage sleep times of the observation group were significantly prolonged

the proportion and efficiency of N3 stage sleep were significantly increased; the sleep latency and wake time of the observation group were significantly shortened

the proportions of N1 and N2 stage sleep were significantly decreased

with statistically significant differences（P<0.05）. The HAMD and HAMA scores were significantly negatively correlated with the total sleep time and N3 stage sleep

and significantly positively correlated with PSQI score. CONCLUSIONS: The combination of modified Chaihu Shugan powder with acupoint application has better overall improvement on subjective sleep quality

objective sleep structure and sleep process in patients with sleep disorder of liver-depression and qi-stagnation

and can alleviate patients’ anxiety and depression

improve their sleep quality. Sleep disorders are correlated with patients’ anxiety and depression status.

关键词

睡眠障碍加味柴胡疏肝散穴位敷贴肝郁气滞睡眠进程睡眠结构

Keywords

Sleep disorderModified Chaihu Shugan powderAcupoint applicationLiver-depression and qi-stagnationSleep processSleep structure

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