OBJECTIVE: To analyze the clinical situation and application of antibiotics during hospitalization in patients with chronic obstructive pulmonary disease（COPD） in Chinese PLA General Hospital（hereinafter referred to as “the hospital”）. METHODS: Data of COPD patients discharged from the hospital in 2020 were reviewed and collected

and the utilization rate

type of application

route of administration

frequency of drug application

course of treatment and drug combination were retrospectively analyzed. RESULTS: Totally 335 patients with COPD were enrolled

more males than females

with an average age of（74.8±10.5） years and an average body mass index of（23.6±4.1） kg/m~2; mainly from cardiovascular medicine department and respiratory medicine department; the main complications were cardiovascular diseases

malignant tumors; the etiological examination specimens were mainly from sputum

and the culture results were mainly gram-negative bacteria. Totally 182 patients were given antibiotics during hospitalization

with the application rate of 54.33%

and the three most commonly used antibiotics were compound preparation of β-lactam/β-lactamase inhibitor（131 cases

71.98%）

fluoroquinolones（68 cases

37.36%） and cephalosporins（40 cases

21.98%）; among which the cefoperazone sodium sulbactam sodium for injection

levofloxacin sodium chloride injection and meropenem for injection were used more frequently; the medication mode was mainly monotherapy（81 cases

44.51%）

the combined application was mainly two drug combination（57 cases

31.32%）

and the patients were treated with an average of（1.9±1.0） kinds of antibiotics. The route of administration was mainly intravenous drip（159 cases

87.36%）. Among the 335 patients with COPD

4 cases were cured

311 cases were improved and discharged

with an overall effective rate of 94.03%（315 cases）. CONCLUSIONS: The individualized and standardized application of antibiotics in COPD patients is of great significance to alleviate patients’ illness and reduce the frequency of deterioration

this hospitals can summarize the characteristics and general rules of antibiotics application in COPD patients

so as to develop corresponding regulatory strategies.