Postoperative cognitive dysfunction（POCD） is a common postoperative complication. A large number of studies have shown that neuroinflammation induced by surgery or narcotic drugs is the main cause of POCD. Tropisetron

as an antagonist of 5-hydroxytryptamine 3 receptor

is an α7nicotinic acetylcholine receptor（α7nAchR） partial agonist

which can reduce central inflammation by regulating multiple inflammatory pathways such as cholinergic anti-inflammatory pathway

p38MAPK signal pathway

cAMP-PKA-CREB signal pathway and SP/NK1R signal pathway

and act on key targets α7nAchR of neurodegenerative diseases

regulate the cholinergic anti-inflammatory pathway to mediate the immune system

and also promote the expression of SIRT1 protein and delay neurodegenerative diseases caused by brain aging by reducing the inhibition of oxidative damage

mitochondrial dysfunction and excessive production of inflammatory mediators. Therefore

as a commonly used antiemetic drug in perioperative period

tropisetron has been found to have a certain neuroprotective properties in clinical application

which can improve POCD. This thesis provides a brief review of the mechanism of tropisetron in improving perioperative cognitive function.