OBJECTIVE: To investigate the occurrence regularity and clinical characteristics of adverse drug reactions（ADR） of ibuprofen and acetaminophen. METHODS: Literature about ADR of ibuprofen and acetaminophen were retrieved from Wanfang Data

CNKI and PubMed（the search time: from Jan. 2000 to Nov. 2021）

and then all literature were statistically analyzed. RESULTS: Totally 135 studies were screened

including 51 ADR studies about ibuprofen and 84 ADR studies about acetaminophen. Among the 51 ADR reports of ibuprofen

the patients were mainly aged ≥70 years old（15 cases

29.4%）; the primary diseases were mainly arthritis and joint pain（22 cases

43.1%）; ADR mainly occurred in ≤1 d after drug administration（30 cases

58.8%）; ADR had involved organs and（or） systems in 128 case-times

including digestive system damage（37 case-times

accounting for 28.9% of the total case-times）

skin and its accessories damage（36 case-times

accounting for 28.1% of the total case-times）; the recovery time was concentrated in 0 to 3 d（19 cases

37.3%）. Among the 84 ADR reports of acetaminophen

the patients were mainly aged <10 years old（29 cases

34.5%）; the primary diseases were mainly upper respiratory tract infection and fever（56 cases

66.7%）; ADR mainly occurred more than 1 to 7 d after treatment（45 cases

53.6%）; ADR had involved organs and（or） systems in 258 case-times

of which the skin and its accessories（109 case-times

accounting for 42.2% of the total case-times） and digestive system（49 case-times

accounting for 19.0% of the total case-times） were more common; the recovery time was concentrated in >7 to 30 d（42 cases

50.0%）. CONCLUSIONS: There are differences in ADR between ibuprofen and acetaminophen in terms of age distribution

primary disease

ADR occurrence time

organ damage and recovery time. In severe ADR

drug anaphylaxis and acute liver injury should be paid attention to.