OBJECTIVE: To systematically evaluate the efficacy and safety of Dantian Jiangzhi pills combined with statins in the treatment of hyperlipidemia. METHODS: By searching Chinese and foreign databases

clinical randomized controlled trials of Dantian Jiangzhi pills combined with statins in the treatment of hyperlipidemia were included（the control group was given statins such as atorvastatin

resulvastatin and simvastatin; the study group received Dantian Jiangzhi pills based on the control group; the dose and duration of treatment were not limited）. RevMan 5.3 was used to analyze the data of the included literature. RESULTS: Totally 9 randomized controlled trials were enrolled

including 1 152 patients. The total effective rate of the study group was higher than that of the control group（OR=3.38

95%CI=2.18-5.26

P<0.000 01）

serum TC（MD=-0.89

95%CI=-1.34--0.43

P=0.000 2） and TG（MD=-0.66

95%CI=-1.03--0.30

P=0.000 3）

LDL-C（MD=-0.61

95%CI=-0.97--0.25

P=0.000 9） and HDL-C（MD=0.28

95%CI=0.16-0.41

P<0.000 01） were better than those in the control group

and the differences were statistically significant. The study group had no obvious adverse drug reactions. CONCLUSIONS: Dantian Jiangzhi pills combined with statins are safe and effective in the treatment of hyperlipidemia.