基于谱-效相关分析的西红花抗抑郁药效成分的研究

李萌; 章从恩; 章前; 于卫东; 陈熹; 马致洁; 赵奎君

doi:10.14009/j.issn.1672-2124.2022.09.017

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基于谱-效相关分析的西红花抗抑郁药效成分的研究

论著 | 更新时间：2023-04-16

- 基于谱-效相关分析的西红花抗抑郁药效成分的研究
- Study on Antidepressant Components of Saffron Based on Spectrum-Effect Correlation Analysis
- 中国医院用药评价与分析 2022年22卷第9期页码：1098-1101
- 作者机构：
  
  1. 首都医科大学附属北京友谊医院中药剂科
  2. 北京科园信海医药经营有限公司
  3. 上海市药材公司
- 作者简介：
- 基金信息：
- DOI：10.14009/j.issn.1672-2124.2022.09.017
  中图分类号： R284.1
- 纸质出版日期：2022，
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李萌, 章从恩, 章前, 等. 基于谱-效相关分析的西红花抗抑郁药效成分的研究[J]. 中国医院用药评价与分析, 2022,22(9):1098-1101.

LI Meng, ZHANG Congen, ZHANG Qian, et al. Study on Antidepressant Components of Saffron Based on Spectrum-Effect Correlation Analysis[J]. 2022,22(9):1098-1101.
李萌, 章从恩, 章前, 等. 基于谱-效相关分析的西红花抗抑郁药效成分的研究[J]. 中国医院用药评价与分析, 2022,22(9):1098-1101. DOI： 10.14009/j.issn.1672-2124.2022.09.017.

LI Meng, ZHANG Congen, ZHANG Qian, et al. Study on Antidepressant Components of Saffron Based on Spectrum-Effect Correlation Analysis[J]. 2022,22(9):1098-1101. DOI： 10.14009/j.issn.1672-2124.2022.09.017.

摘要

目的：基于谱-效相关分析方法，对西红花体外抗抑郁药效成分进行筛选。方法：运用液相色谱质谱联用(LC-MS)技术，对10个不同产地西红花的化学成分进行测定并初步指认；以皮质酮诱导PC12细胞损伤建立抑郁体外模型，采用CCK-8试剂盒检测细胞存活率，评价西红花的体外抗抑郁效应。采用相关回归分析方法，分析效应与成分之间的关系。结果：指认出西红花中5个主要化学成分；确认PC12细胞损伤模型可以有效评价西红花体外抗抑郁效应；通过简单及多元相关回归分析可知，西红花苷-Ⅰ、西红花苷-Ⅱ、藏花醛与西红花抗抑郁效应有较大相关性。结论：西红花苷-Ⅰ、西红花苷-Ⅱ、藏花醛可能与西红花抗抑郁作用相关性较高。

Abstract

OBJECTIVE: To screen the antidepressant components of saffron based on spectrum-effect correlation analysis. METHODS: Liquid chromatography-mass spectrometry（LC-MS） technology was used to characterize the chemical components of saffron samples from ten different regions. An in vitro model of depression was established on PC12 cells injury induced by corticosterone. The survival rate of cell was measured by CCK-8

and the antidepressant effects of saffron were evaluated. The correlation between effects and components was analyzed by regression analysis. RESULTS: Five kinds of main components were identified. And the model of PC12 cells injury as carrier was able to evaluate the antidepressant effect in vitro. Through the simple and multiple regression analysis

crocin-Ⅰ

crocin-Ⅱ and safranal were closely related to the the antidepressant components of saffron. CONCLUSIONS:Crocin-Ⅰ

crocin-Ⅱ and safranal may be highly correlated with the antidepressant effect of saffron.

关键词

西红花PC12细胞抑郁谱-效相关

Keywords

SaffronPC12 cellsDepressionSpectrum-effect correlation

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