OBJECTIVE: To compare the effects of patient-controlled intravenous analgesia（PCIA） versus programmed intermittent epidural bolus（PIEB） administration in nalbuphine patients on labour analgesia.METHODS: A total of 68 full-term

singleton

and cephalic pregnant women admitted into the hospital from Nov. 2020 to Aug. 2021 were extracted to be divided into the PCIA group and PIEB group according to different analgesic method

with 34 cases in each group. The visual analogue score of pain（VAS）

heart rate（HR） and mean arterial pressure（MAP） at the time of admission to the delivery room

at 2 cm opening

at 3 cm opening

at 4 cm opening

at full opening and at the time of delivery were compared between two groups. The dosage of analgesic pump liquid and the duration of labor were compared between two groups. The neonatal Apgar score

neonatal behavioral neurological assessment（NBNA） score

and the incidence of adverse drug reactions were compared between two groups. RESULTS: There was no statistically significant difference between two groups in the VAS scores at the time of admission to the delivery room

at 2 cm opening

at 3 cm opening

at 4 cm opening

at full opening and at the time of delivery（P>0.05）. There was no statistically significant difference between groups

between time points and between groups·time points in the comparison of HR and MAP levels at different moments in both groups（P>0.05）. The dosage of analgesic pump in the PIEB group was lower than that in PCIA group

and the duration of the second stage of labor was shorter than that in PCIA group

the differences were statistically significant（P<0.05）. There was no significant difference in the duration of the first stage of labor and the third stage of labor between two groups（P>0.05）. There was no statistically significant difference in the 1 min Apgar score

5 min Apgar score and 24 h NBNA score between two groups of neonates（P>0.05）. The incidence of urinary retention in the PIEB group was lower than that in PCIA group

with statistically significant differences（P<0.05）. CONCLUSIONS: The administration of nalbuphine PIEB for labor analgesia can obtain similar analgesic effect and hemodynamic stabilization effect as PCIA

reduce the dosage of analgesic pump liquid and urinary retention

and shorten the duration of the second stage of labor without affecting maternal and neonatal conditions

and has clinical application advantages.