OBJECTIVE: To probe into the clinical efficacy of Liangxue Huoxue recipe application in the treatment of acute gouty arthritis of dampness-heat accumulation type and its effect on T helper cells 17/T regulatory cells（Th17/Treg） cell balance. METHODS: A total of 80 patients with acute gouty arthritis admitted into the hospital from Jun. 2019 to Mar. 2021 were extracted to be divided into the observation group and the control group via the random number table method（with 40 cases in each group）. The control group was treated with basic treatment regimen

while the observation group received Liangxue Huoxue formula application based on the basic treatment regimen. Clinical efficacy

traditional Chinese medicine symptom scores

Th17（CD3

+

CD4

+

IL-17

+

）

Treg（CD4

+

CD25

+

CD127

+

） cell percentage and Th17/Treg ratio of CD4

+

T lymphocytes

serum uric acid（UA）

erythrocyte sedimentation rate（ESR）

transforming growth factor-β1（TGF-β1）

interleukin-17（IL-17） and C-reactive protein（CRP） levels before and after treatment of two groups were compared. RESULTS: After treatment

the traditional Chinese medicine symptom scores of two groups decreased significantly

and the improvement in the observation group was more significant

and the differences were statistically significant（P

<

0.05）. The total effective rate of the observation group was 97.50%（39/40）

and that of the control group was 85.00%（34/40）

the difference was statistically significant（χ~2=3.914

P

<

0.05）. After treatment

the Th17 cell percentage and Th17/Treg ratio in two groups decreased significantly

and the improvement in the observation group was more significant

the differences were statistically significant（P

<

0.05）;the Treg cell percentage in two groups increased significantly

and the improvement in the observation group was more significant

the differences were statistically significant（P

<

0.05）. After treatment

the levels of UA

ESR

IL-17 and CRP in two groups decreased significantly

and the improvement in the observation group was more significant

with statistically significant differences（P

<

0.05）;the level of TGF-β1 in two groups increased significantly

and the improvement in the observation group was more significant

with statistically significant differences（P

<

0.05）. CONCLUSIONS: Liangxue Huoxue recipe application can effectively improve the UA level of patients with acute gouty arthritis of dampness-heat accumulation type

reduce the inflammatory response

and regulate the balance of Th17/Treg cells.