OBJECTIVE: To probe into the efficacy of compound Zaofan pills combined with recombinant human granulocyte colony-stimulating factor（rhG-CSF） in the treatment of leukopenia after tumor chemotherapy. METHODS: A total of 94 patients with leukopenia after tumor chemotherapy admitted into the hospital in 2021 were extracted to be divided into the control group and the observation group via the random number table method

with 47 cases in each group. The control group received rhG-CSF treatment

while the observation group was given compound Zaofan pills combined with rhG-CSF treatment. The clinical efficacy

traditional Chinese medicine syndrome score

incidence of adverse drug reactions

peripheral blood white blood cell（WBC） count

neutrophil count（NEUT）

CD3

+

CD4

+

CD8

+

and CD4

+

/CD8

+

were compared between two groups. RESULTS: The total effective rate of the observation group was 89.36%（42/47）

significantly higher than 72.34%（34/47） of the control group

the difference was statistically significant（P

<

0.05）. After treatment

the traditional Chinese medicine syndrome score and peripheral blood CD8

+

levels decreased significantly

while peripheral blood WBC

NEUT

CD3

+

CD4

+

and CD4

+

/CD8

+

levels increased significantly in two groups; the traditional Chinese medicine syndrome score and peripheral blood CD8

+

levels of the observation group were significantly lower than those of the control group

and the peripheral blood WBC

NEUT

CD3

+

CD4

+

and CD4

+

/CD8

+

levels of the observation group were significantly higher than those of the control group

the differences were statistically significant（P

<

0.05）. The incidence of adverse drug reactions in the control group and the observation group were respectively 17.02%（8/47） and 12.77%（6/47）

and there was no significant difference between two groups（P

>

0.05）. CONCLUSIONS: The efficacy of Zaofan pills combined with rhG-CSF in the treatment of leukopenia after tumor chemotherapy is significant

which can effectively increase the WBC and improve the immune function with higher safety.