OBJECTIVE: To investigate the medication on patients with systemic lupus erythematosus（SLE） in outpatient and emergency prescriptions in 9 cities in China

and propose reasonable suggestions

so as to provide reference for clinical rational drug use. METHODS: All the prescriptions of immunization drugs were randomly selected by quarter from 109 sample medical institutions in 9 cities including Beijing

Chengdu and Guangzhou from 2016 to 2020

the medication of patients were collected and analyzed. The defined daily dose（DDDs）

defined daily cost（DDC） and growth rate of consumption sum of drugs for SLE were calculated

and then analyzed for the clinical application. RESULTS: A total of 480 886 prescriptions were enrolled in this study. The statistical results showed that the age of SLE patients was mainly >20 to 40 years old（222 492 person-times）; there were more female patients（412 894 person-times） than male patients（47 373 person-times）. From 2016 to 2020

the total consumption sum of drugs for SLE patients in 9 cities increased steadily

and the drug with the highest consumption sum was mycophenolate mofetil; the drug with the highest DDDs was prednisone

followed by hydroxychloroquine

and the DDDs of prednisone increased year by year from 2016 to 2019（decreased in 2020）

the DDDs of hydroxychloroquine increased year by year for the 5 years. CONCLUSIONS: The total consumption sum of therapeutic drugs for SLE patients in 9 cities in China from 2016 to 2020 shows an increasing trend; although the medication on SLE patients varies from each city

it is generally in line with the guideline recommended drug use; meanwhile

more attention should be paid to the safety of individual drugs.