OBJECTIVE: To probe into the medication rules of traditional Chinese medicine in the treatment of liver cancer after transcatheter arterial chemoembolization（TACE） based on data mining

so as to provide reference for traditional Chinese medicine in the treatment of liver cancer after TACE. METHODS: Seven domestic and foreign databases were retrieved

relevant literature were screened

and information on prescriptions of traditional Chinese medicine in the treatment of liver cancer after TACE was extracted. SPSS Statistics 25 and SPSS Modeler 18 software were used to explore and analyze the frequency

properties and taste

correlation degree and clustering of traditional Chinese medicine after TACE for liver cancer. RESULTS: A total of 143 traditional Chinese medicines and 216 herbs were extracted

and the cumulative frequency used in herbs was 1 407 times. After analysis

there were 6 medicines with the frequency of >50 times（the frequency from high to low was licorice

bupleurum

poria

atractylodes macrocephala koidz

white peony root and radix codonopsis）. The 16 traditional Chinese medicines used >20 times could be divided into 5 categories according to the efficacy

namely tonic drugs（9 types

56.2%）

heat-clearing drugs（2 types

12.5%）

and damp-drying and phlegm-resolving drugs（2 types

12.5%）

Qi-regulating drugs（2 types

12.5%） and cold-dispelling drugs（1 type

6.2%）. The properties of the included traditional Chinese medicines were mainly warm

calm and cold

the majority of the medicinal flavors were pungent

sweet and bitter

and the most common meridian were the stomach and kidney meridians. Correlation analysis and cluster analysis formed a core drug formula based on bupleurum

poria

atractylodes macrocephala koidz and licorice. CONCLUSIONS: It is recommended to take Chaishao Liujunzi decoction as the main formula

on this basis

with the use of heat-clearing

damp-drying and phlegm-resolving

Qi-regulating and blood circulation-promoting drugs.