OBJECTIVE: To probe into the influencing factors of digoxin blood concentration（SDC） in the hospital. METHODS: Based on the system query method

the SDC of inpatients in the hospital from Jan. 2019 to Oct. 2021 were summarized. SDC

age

gender

creatinine clearance rate（CrCl）

potassium level and drug combination of inpatients with therapeutic drug monitoring during digoxin treatment were statistically analyzed by retrospective study. RESULTS: A total of 418 inpatients monitored for SDC were included

and the average SDC was（1.22±0.98）ng/mL; among them

171 patients（40.91%） had SDC within the normal range

200 patients（47.85%） had SDC <0.50 ng/mL

and 47 patients（11.24%） had SDC >1.75 ng/mL. Gender

age

CrCl（<30 mL/min） and combined application with macrolide antibiotics had significant effects on SDC（P<0.05）. CONCLUSIONS: Only about 40% of patients using digoxin in this hospital had SDCs within the effective therapeutic window

and >45% had SDCs below the minimum effective therapeutic concentration

indicating that the clinical dose is conservative. When using digoxin

clinicians and clinical pharmacists should pay attention to patients’ age

gender

CrCl and combined application with macrolide antibiotics and potassium-removing diuretics

and timely adjust the dosage for patients with abnormal SDC monitoring results to improve the clinical treatment effect.