OBJECTIVE: To probe into the clinical efficacy of tonifying kidney

resolving phlegm and promoting blood circulation combined with clomifene citrate in the treatment of ovulatory dysfunction infertility of polycystic ovary syndrome（PCOS） with kidney deficiency and blood stasis. METHODS: From Jun. 2019 to Jun. 2020

84 patients with ovulatory dysfunction infertility of PCOS with kidney deficiency and blood stasis admitted into the hospital were divided into the group A（n=42） and the group B（n=42） according to the random number table method. The group A was treated with clomifene citrate

while the group B received tonifying kidney

resolving phlegm and promoting blood circulation combined with clomifene citrate. Changes of thyroid hormone level

endometrial receptivity and ovarian ovulation before and after treatment in two groups were observed

and the efficacy and safety of medication in two groups were evaluated. RESULTS: After treatment

the serum levels of triiodothyronine and thyroxine in group B were significantly higher than those in group A

and the serum level of thyroid-stimulating hormone was significantly lower than that in group A

the differences were statistically significant（P<0.05）. After treatment

the average ovarian volume in group B was significantly smaller than that in group A

the uterine artery resistance index in group B was significantly lower than that in group A

and the endometrial thickness and uterine artery pulse index were significantly higher than those in group A

with statistically significant difference（P<0.05）. After treatment

the number of follicles in group B were significantly lower than those in group A

and the diameter of main follicles was significantly longer than that in group A

with statistically significant difference（P<0.05）. The total effective rate of group B（90.48%

38/42） was significantly higher than that of group A（73.81%

31/42）

the difference was statistically significant（P<0.05）. During the medication period

the total incidence of adverse reactions in group A was 9.52%（4/42） and that in group B was 11.90%（5/42）

there was no significant difference between two groups（P>0.05）. CONCLUSIONS: The efficacy of tonifying kidney

resolving phlegm and promoting blood circulation combined with clomifene citrate in the treatment of ovulatory dysfunction infertility of PCOS with kidney deficiency and blood stasis is significant

which can promote ovulation

effectively regulate thyroid hormone level

improve endometrial receptivity and increase implantation rate.