OBJECTIVE: To probe into the effects of Qingre Huatan decoction combined with Sangbaipi decoction on pulmonary ventilation function and immune function in patients with chronic obstructive pulmonary disease（COPD） of phlegm-heat stagnation type. METHODS: A total of 92 patients with COPD of phlegm-heat stagnation type admitted into our hospital from Nov. 2019 to Nov. 2020 were prospectively selected to be divided into the control group and the observation group via the random number table

with 46 cases in each group. Both groups were given western medicine treatment. On this basis

the control group was treated with Sangbaipi decoction

while the observation group received Sangbaipi decoction combined with Qingre Huatan decoction. After treatment of 40 d

the clinical symptoms and pulmonary function were compared between two groups. The levels of T lymphocyte subsets

tumor necrosis factor-α（TNF-α）

transforming growth factor-β1（TGF-β1） and C-reactive protein（CRP） were measured

and the clinical efficacy was observed. RESULTS: After treatment

the traditional Chinese medicine syndrome scores of chest tightness

cough and expectoration symptoms decreased significantly in two groups; compared with the control group

the traditional Chinese medicine syndrome scores of chest tightness

cough and sputum in the observation group were significantly lower

the differences were statistically significant（P

<

0.05）. After treatment

the maximum expiratory flow（MEF）

forced vital capacity（FVC） and forced expiratory volume in one second（FEV

1

） levels of two groups increased significantly; compared with the control group

the levels of MEF

FVC and FEV

1

in the observation group were significantly higher

the differences were statistically significant（P

<

0.05）. After treatment

the serum levels of CD4

+

and CD4

+

/CD8

+

increased

while the levels of CD8

+

TNF-α

TGF-β1 and CRP decreased in two groups; compared with the control group

the serum levels of CD4

+

and CD4

+

/CD8

+

in the observation group were higher

and the levels of CD8

+

TNF-α

TGF-β1 and CRP were lower

with statistically significant difference（P

<

0.05）. Compared with the control group（82.61%

38/46）

the total effective rate of the observation group was significantly higher（97.83%

45/46）

and the difference was statistically significant（P

<

0.05）. CONCLUSIONS: The clinical efficacy of Qingre Huatan decoction combined with Sangbaipi decoction on the basis of western medicine in the treatment of COPD of phlegm-heat stagnation type is significant

which can reduce the traditional Chinese medicine syndrome score of patients

effectively inhibit the spread of inflammatory reaction

improve the immune function

and contribute to the recovery of pulmonary ventilation function of patients.