OBJECTIVE: To probe into the correlation between efficacy

blood concentration and dose of levetiracetam in the treatment of children with epilepsy

so as to provide a certain reference for the medication of levetiracetam in children. METHODS: Levetiracetam blood concentration and epilepsy frequency were analyzed by NONMEN software and oracle crystal ball software. RESULTS: NONMEM software analysis showed that the efficacy tended to become better as the levetiracetam blood concentration increased. When the epilepsy control rate was 50%

the corresponding blood concentration was 24 μg/mL. When the blood concentration reached 36 μg/mL

the increase of epilepsy control rate was not significant. Analysis results of oracle crystal ball software showed that the optimal dosage of levetiracetam in the treatment of children with epilepsy was from 20 mg/（kg·d） to 48 mg/（kg·d）. CONCLUSIONS: The blood concentration of levetiracetam has a certain correlation with the efficacy

but it is not that the higher the drug concentration

the better the efficacy. The treatment of epilepsy in children requires individualized medication.