OBJECTIVE: To comprehensively evaluate the efficacy

safety and economy of total glucosides of Paeoniae paeoniae capsules in the treatment of oral lichen planus

so as to provide relevant evidence-based evidence for clinical use. METHODS: Wanfang Data

CNKI

CBM

Embase

the Cochrane Library and PubMed

and the health technology assessment（HTA） official website were retrieved to collect the HTA report

Meta-analysis/systematic evaluation and pharmacoeconomic studies of total glucosides of Paeoniae paeoniae capsules. The retrieval time was from the establishment of the database to Nov. 30 th

2021.The qualitative description method was used to analyze and summarize the included literature

and the quality of literature and its methodology was evaluated by using relevant scales. RESULTS: A total of 3 articles were included

all of which were related Meta-analysis/systematic evaluation of total glucosides of Paeoniae paeoniae capsules in the treatment of oral lichen planus

yet neither HTA report nor pharmacoeconomics studies was retrieved. On the basis of conventional western medicine treatment

combined with total glucosides of Paeoniae paeoniae capsules in the treatment of oral lichen planus

the clinical efficacy was generally better than that of western medicine conventional treatment

which had certain advantages in relieving painful symptoms

improving the symptoms of congestion and erosion and the degree of leukoplakia regression

improving the levels of CD3

CD4

CD8 and CD4/CD8 of peripheral blood T lymphocyte subsets

and reducing the recurrence rate

etc. Meanwhile

the incidence of adverse drug reactions was low

the symptoms were mild

and the safety was good. CONCLUSIONS: On the basis of conventional treatment

combined with total glucosides of Paeoniae paeoniae capsules in the treatment of oral lichen planus has higher safety and efficacy. Further pharmacoeconomic studies on the drugs may be considered to supplement the evidence from the economic evaluation of Paeoniae paeoniae capsules in the treatment of oral lichen planus.