OBJECTIVE: To probe into the clinical efficacy and rehabilitation of sertraline combined with contract learning in the treatment of patients with obsessive-compulsive disorder. METHODS: The working group for the treatment and rehabilitation of sertraline combined with contract learning method was established. Totally 60 patients with obsessive-compulsive disorder admitted into the hospital from Sept. 2019 to Mar. 2020 were extracted to be divided into the observation group and the control group via the random number table

with 30 cases in each group. The control group received sertraline combined with daily rehabilitation training in the hospital

while the observation group was given the contract learning method on the basis of the control group. Clinical effects and adverse drug reactions of two groups were compared. The Yale-Brown obsessive-compulsive scale（Y-BOCS） and Hamilton depression scale（HAMD） were used to evaluate the rehabilitation effect. The treatment emergent symptom scale（TESS） was used to evaluate the safety of two groups. RESULTS: At the 1 st

2 nd and 4 th week of treatment

there was no significant difference in the effective rate between two groups（P>0.05）. At the end of the 6 th week of treatment

the effective rate of the observation group was 76.67%（23/30）

significantly higher than 50.00%（15/30） of the control group

with statistically significant difference（P<0.05）. Compared with the control group

the Y-BOCS score and HAMD score of the observation group decreased significantly at the time of discharge and at the 1 st and 6 th months after discharge

with statistically significant difference（P<0.05）. There was no significant difference in the TESS scores between two groups at the time of discharge and at the 1 st and 6 th months after discharge（P>0.05）. CONCLUSIONS: Sertraline combined with contract learning method is more effective than sertraline combined with daily hospital rehabilitation care for patients with obsessive-compulsive disorder and has higher safety.