OBJECTIVE: To probe into the application value of osteoking after percutaneous vertebroplasty/percutaneous kyphoplasty（PKP） for osteoporotic vertebral compression fracture（OVCF）

and its effects on bone metabolism and bone mineral density of patients. METHODS: A total of 66 patients with OVCF undergoing PKP surgery in our hospital from Jun. 2019 to Jun. 2020 were extracted to be divided into the control group and the observation group via the random number table

with 33 cases in each group. The control group was treated with standard anti-osteoporosis scheme after surgery

while the observation group received osteoking on the basis of the control group

both groups were treated for 12 weeks. The efficacy

time of fracture healing were compared between two groups. Changes of bone metabolism and bone mineral density were observed before and after treatment

and the new fractures were followed up. RESULTS: The total effective rate of the observation group was 100.00%

higher than that of the control group（87.88%

29/33）

and the time of fracture healing of the observation group was shorter than that of the control group

with statistically significant differences（P

<

0.05）. After treatment

the levels of serum alkaline phosphatase（ALP） and osteocalcin（BGP） in both groups increased compared with before treatment

while the urinary tartrate-resistant acid phosphatase（U-TRAP）

urinary calcium/creatinine(U-Ca

2+

/Cr) and urinary hydroxyproline/creatinine（U-HYP/Cr） decreased compared with before treatment; after treatment

the levels of ALP and BGP in the observation group were higher than those in the control group

while U-Trap

U-Ca

2+

/Cr and U-HYP/Cr in the observation group were lower than those in the control group

the differences were statistically significant（P

<

0.05）. After treatment

the bone mineral density of lumbar spine L

2—4

and femoral neck of two groups increased compared with before treatment

and the bone mineral density of lumbar spine L

2—4

and femoral neck of the observation group was higher than that of the control group

the differences were statistically significant（P

<

0.05）. The rate of new fracture in the observation group was 3.03%（1/33）

significantly lower than 18.18%（6/33） in the control group

with statistically significant differences（P

<

0.05）. CONCLUSIONS: Osteoking can significantly promote the bone formation

inhibit the bone resorption and enhance the bone mineral density in patients with OVCF

which is of positive significance to promote early fracture healing and prevent recurrent vertebral fractures.