OBJECTIVE: Toprobe into theclinical efficacy of Xueshuantong for injection（Lyophilized） combined withClopidogrel hydrogen sulfate tablets in the treatment of acute ischemic stroke. METHODS: Patients with acute ischemic stroke admitted into this Hospital from Oct. 2020 to Oct. 2021 and had onset within 72 h without throm bolytic therapy were retrospectively selected.Thirty patients were randomly extracted from the patients treated with Xueshuantong for injection（Lyophilized） combined with Clopidogrel hydrogen sulfate tablets as the study group

andthi rty patients were randomly selected from the patients treated with clop idogrel hydrogen sulfate tablets as the cont rolgroup. After treatment of 2 weeks

the NIHSS score

plasma fibrinogenand homocysteine levels

total effective rateand incidence of adverse drug reactions were compared two groups before and after treatment. RESULTS: After treatment

the NIHSS score

plasma fibrinogen and betweenhomocysteine levels in the study group were significantly lowerthan those in the control group

with statistical significant differences（P<0. 05）. After treatment of 2 weeks

the total effective rate of the study group was 86. 67%（26/30）

significantly higher than that of the control group（63. 33%

19/30）

the difference was statistically significant（P<0. 05）. The incidence of adverse drug reactions in thestudy group was 10. 00%（ 3/30）

slightly higher than that in the control group（ 3. 33%

1/30）

with no statisticalsignificant difference（P>0. 05）. CONCLUSIONS: For patients with acute ischemic stroke

Xueshuantong for injection（ Lyophilized） combined with clopidogrel hydrogen sulfate tablets has higher total effective rate than clopidogrel hydrogen sulfate tablets alone

which can reduce the NIHSS score

plasma fibrinogen and homocysteine levels

and there was no significant increase in the risk of adverse drug reactions.