OBJECTIVE: To investigate the characteristics of adverse drug reactions（ADR） induced by iohexol

to indicate the possible safety risks of clinical medication

so as to provide basis for rational clinical application of iohexol. METHODS: Retrospective analysis was performed on the ADR reports induced by iohexol collected from the National Center for ADR Monitoring System in Beijing from 2016 to 2020. RESULTS: A total of 799 cases of ADR induced by iohexol were collected

including 29 cases of severe ADR and 770 cases of general ADR. There were 395 male patients（49.44%）

402 female patients（50.31%）

and 2 patients with unknown gender

indicating a balanced gender ratio. Patients aged >50 to 70 years were the most（442 cases）. The clinical manifestations of ADR were skin and its accessory lesions

systemic lesions and gastrointestinal lesions. CONCLUSIONS: The general ADR induced by iohexol are generally tolerated. Although the ADR of non-ionic iodine contrast agent are less than that of ionic iodine contrast agent

there are still risks of severe allergy

shock

vagus reaction

cardiac complications and embolism. The risks of medication should be carefully evaluated before and after medication

and hydration should be performed on patients before and after examination. During and after the examination

patients should be closely observed for any symptoms of discomfort. It is encouraged to report ADR and update evidence-based evidence in a timely manner

and revise the new ADR into drug instructions to reduce the risk of medication for patients and better promote the rational clinical application of iohexol.