OBJECTIVE: To investigate the characteristics

rules and features of adverse drug reactions（ADR） induced by protein and peptide drugs. METHODS: Pareto analysis was performed on 127 cases of ADR induced by protein and peptide drugs in Hebei General Hospital and the Fourth Hospital of Hebei Medical University from 2014 to 2021. RESULTS: Among 127 cases of ADR induced by protein and peptide drugs

most patients aged from 40 to <80 years（95 cases

74.80%）. Intravenous administration was the main route of administration（96 cases

75.59%）. Among the drugs involved in ADR

the cumulative composition ratio of the number of ADR cases for immunomodulatory drugs

drugs for improving brain metabolism and antidiabetic drugs was in the range from 0% to 80%

which were the main influencing factors. The drugs with the highest proportion of ADR cases were immunomodulatory drugs（56 cases

44.09%）

followed by drugs for improving brain metabolism（22 cases

17.32%） and antidiabetic drugs（20 cases

15.75%）. There were 232 case-times of clinical manifestations of ADR induced by protein and peptide drugs

mainly skin and its accessory damage（75 case-times

32.33%）

followed by systemic damage（45 case-times

19.40%）. CONCLUSIONS: Protein and peptide drugs are prone to induce ADR

especially immunomodulatory drugs

and the supervision of such drugs should be strengthened to ensure rational clinical drug use.