OBJECTIVE: To probe into the efficacy and safety of Xingnaojing injection combined with naloxone hydrochloride on senile patients with acute stroke complicated with disturbance of consciousness. METHODS: Totally 95 senile patients with acute stroke complicated with disturbance of consciousness admitted from Jan. 2019 to Dec. 2020 were extracted to be divided into the observation group（n=52） and the control group（n=43） via random number table method with odd and even numbers at the end of hospitalization number. On the basis of conventional treatment

the control group was treated with naloxone hydrochloride injection

while the observation group received Xingnaojing injection combined with naloxone hydrochloride injection. Changes of inflammatory factors

nerve cytokines

nerve function indexes

efficacy and safety were observed in two groups. RESULTS: After treatment of two weeks

the levels of serum lipoprotein associated phospholipase A2

soluble interleukin-2 receptor

neuron specific enolase in the observation group were significantly lower than those in the control group

and the level of brain-derived neurotrophic factor was significantly higher than that in the control group

with statistically significant difference（P<0.05）. The national institutes of health stroke scale in the observation group was lower than that of the control group

and the Glasgow coma score was higher than that of the control group

with statistically significant difference（P<0.05）. The total effective rate in the observation group（96.15%

50/52） was significantly higher than that in the control group（83.72%

36/43）

the recovery time and length of stay were significantly shorter than those in the control group

and the incidence of cardiovascular adverse events（3.85%

2/52） was significantly lower than the control group（9.30%

4/43）

and the difference was statistically significant（P<0.05）. There was no statistical significance in the incidence of adverse drug reactions between two groups（P>0.05）. CONCLUSIONS: Xingnaojing injection can reduce the inflammatory state of senile patients with acute stroke complicated with disturbance of consciousness

regulate the level of nerve cytokines

promote the recovery of consciousness level and improve the prognosis of disease with higher safety.