OBJECTIVE: To probe into the effects of low-dose aminophylline combined with adaptive stress support therapy on chest-lung compliance and cerebral oxygen metabolism in patients with acute exacerbation of chronic obstructive pulmonary disease（AECOPD） complicated with severe respiratory failure. METHODS: Clinical data of 92 patients with AECOPD complicated with severe respiratory failure admitted to our hospital from Oct. 2019 to Mar. 2021 were collected for retrospective analysis

which were divided into observation group and control group according to different therapeutic regimens

with 46 cases in each group. The control group was given adaptive stress support therapy

while the observation group was given low-dose aminophylline combined with adaptive stress support therapy. The duration of mechanical ventilation and length of hospital stay

blood gas indicators [oxygen partial pressure（PaO

2

）

partial pressure of carbon dioxide（PaCO

2

）

oxyhemoglobin saturation（SpO

2

） and carbon dioxide combining power（CO

2

CP）]

chest-lung compliance [respiratory system compliance(C

rs

)

chest wide compliance(C

cw

) and lung compliance（C

l

）]

cerebral oxygen metabolism [oxyhemoglobin saturation of jugular vein bulb（SjvO

2

）

cerebral oxygen extraction rate（CEO

2

） and deviation of oxyhemoglobin saturation of artery and vein（Ca-vO

2

）] and inflammatory factor levels [interleukin（IL） 17

myeloid cells trigger receptors 1（TREM-1） and IL-33]

before treatment and after 3 days of treatment

incidences of adverse drug reactions during treatment were compared between two groups. RESULTS: The duration of mechanical ventilation and length of hospital stay of the observation group were shorter than those of the control group

with statistically significant differences（P

<

0.05）. After 3 days of treatment

the PaO

2

SpO

2

C

rs

C

cw

C

l

and SjvO

2

levels of observation group were higher than those of the control group

while the PaCO

2

CO

2

CP

Ca-vO

2

and CEO

2

levels of observation group were lower than those of the control group

with statistically significant differences（P

<

0.05）. After 3 days of treatment

the serum IL-17

TREM-1 and IL-33 levels of observation group were lower than those of the control group

with statistically significant differences（P

<

0.05）. The incidences of adverse drug reactions of observation group and control group were respectively 10.87%（5/46） and 6.52%（3/46）

the difference was not statistically significant（P

>

0.05）. CONCLUSIONS: Low-dose aminophylline combined with adaptive stress support therapy in the treatment of AECOPD complicated with severe respiratory failure can effectively shorten the duration of mechanical ventilation and length of hospital stay

improve respiratory status

chest-lung compliance and cerebral oxygen metabolism

relieve body inflammation

with high safety.