OBJECTIVE: To probe into the efficacy of Zishen Ningxin capsules in the treatment of perimenopausal hypertension and its effect on sex hormone level and insulin resistance. METHODS: Totally 100 patients with perimenopausal hypertension admitted into Shijiazhuang Hospital of Traditional Chinese Medicine from Sept. 2020 to Jun. 2021 were selected and randomly divided into control group and research group

with 50 cases in each group. The control group was given valsartan tablets

while the research group were given Zishen Ningxin capsules based on the control group

both group were treated for 1 month. The testosterone（T）

progesterone（P）

sex hormone binding protein（SHGB）

estrogen（E

2

）

neurotensin（NT）

neuropeptide Y（NPY）

prostacyclin（PGI

2

）

angiotensin Ⅱ（AngⅡ）

Chemerin protein

diastolic blood pressure and systolic blood pressure levels were measured before and after treatment

the insulin resistance index（HOMA-IR） was calculated

Kupperman score and traditional Chinese medicine（TCM）syndrome evaluation were performed on the patients

so that the clinical efficacy was compared between two groups. RESULTS: Compared with the control group

the E

2

SHBG

NT and PGI

2

levels of research group were increased after treatment

the NPY

AngⅡ

P

T

Chemerin protein

HOMA-IR

diastolic blood pressure and systolic blood pressure levels

Kupperman score and TCM syndrome integral of research group were decreased after treatment

with statistically significant differences（P

<

0.05）. The total effective rate of research group was 96.00%（48/50）

which was higher than 80.00%（40/50） in the control group

with statistically significant difference（P

<

0.05）. CONCLUSIONS: Zishen Ningxin capsules for the treatment of perimenopausal hypertension can improve patients’ sex hormone disorder

regulate NT

PGI

2

AngⅡ and NPY levels

improve blood pressure and insulin resistance

and promote the clinical efficacy.