OBJECTIVE: To investigate the clinical effect of self-made Wenyang Tongluo decoction in the treatment of diabetic peripheral neuropathy（DPN） of yang-deficiency and blood-stasis syndrome. METHODS: According to the envelope lottery method

totally 120 patients with DPN yang-deficiency and blood-stasis syndrome admitted into this hospital from Apr. 2019 to Jun. 2021 were equally divided into control group and research group. The control group was given conventional therapy

the research group was given self-made Wenyang Tongluo decoction based on the control group. The efficacy

TCM symptom integral

indicators of blood glucose metabolism

nerve conduction velocity

inflammatory factors and incidences of adverse drug reactions were compared between two groups. RESULTS: The total effective rate of the research group was 93.33%（56/60）

which was higher than 73.33%（44/60） in the control group

with statistically significant difference（P<0.05）. After 4 weeks of treatment

the numbness

burning sensation

abnormal sensation and end-of-limb pain scores

fasting blood glucose

2 h postprandial blood glucose

interleukin（IL） 1β

IL-18 and tumor necrosis factor α levels of both groups were lower than before treatment

and those of the research group were lower than the control group

with statistically significant differences（P<0.05）. After 4 weeks of treatment

the motor nerve conduction velocity and sensory nerve conduction velocity of median nerve and right peroneal nerve of both groups were faster than before treatment

and those of the research group were faster than the control group

with statistically significant differences（P<0.05）. No significant adverse drug reactions were observed in both groups. CONCLUSIONS: The self-made Wenyang Tongluo decoction in the treatment of DPN of yang-deficiency and blood-stasis syndrome can improve the nerve conduction velocity and reduce the inflammatory response

with significant efficacy.