OBJECTIVE: To summarize the clinical characteristics of acute kidney injury（AKI） induced by rabeprazole

so as to provide reference for the safe use of rabeprazole in clinic. METHODS: MEDLINE

CNKI

Wanfang Data and VIP database were retrieved to collect the case reports of AKI induced by rabeprazole

the retrieval time was from the establishment of the database to Jul. 6 th

2021. Statistical and descriptive analysis was performed on relevant data. RESULTS: Seven literatures were included

with a total of 7 cases

including 5 cases of acute interstitial nephritis

1 case of acute tubular necrosis

and 1 case of AKI was induced by rhabdomyolysis. The patients ranged in age from 57 to 84 years old [mean（66.6±10.1） years old]

with 4 males（57.1%） and 3 females（42.9%）. The daily dose of rabeprazole was from 10 mg to 20 mg

only one case was 40 mg

and the treatment course ranged from 2 d to 6 months. Clinical characteristics of AKI induced by rabeprazole were mainly fatigue

nausea

hematuria

proteinuria

anemia

elevated blood creatinine levels and elevated blood urea nitrogen levels. Serum creatinine levels in patients with AKI ranged from 113 μmol/L to 469 μmol/L [mean（267.7±107.7） μmol/L]. Five patients were treated with glucocorticoid and followed up for 10 d to 18 months

the serum creatinine levels recovered to 97 μmol/L to 150 μmol/L [mean（118.5±21.5） μmol/L]. CONCLUSIONS: AKI induced by rabeprazole is mainly acute interstitial nephritis

and its indications should be strictly controlled in clinical use

and the serum creatinine level of patients should be monitored.