OBJECTIVE: To investigate the adverse drug reactions of liver injury induced by radix polygoni multiflori decoction pieces and its preparations

so as to provide reference for rational drug use in clinic. METHODS: Case reports of adverse drug reactions in Wanfang Data

VIP and CNKI from 1989 to 2020 were retrieved by using the keyword “liver injury induced by radix polygoni multiflori”. Gender

age

duration of medication and frequency of adverse drug reactions were recorded

and the data were analyzed by χ~2 test. RESULTS: A total of 48 literature and 57 cases were retrieved. The frequency of adverse drug reactions of liver injury induced by radix polygoni multiflori decoction pieces and its preparations was not significantly related to the gender and age of the patients（P>0.05）

but was significantly related to the duration of medication（P<0.05）. CONCLUSIONS: Adverse drug reactions of liver injury induced by radix polygoni multiflori decoction pieces and its preparations can not be ignored. In clinical application

close attention should be paid to the reaction of patients after taking the medicine to reduce the incidence of adverse drug reactions and ensure the safety of medication.