OBJECTIVE: To systematically evaluate the clinical efficacy of using fluorescein sodium injection to guide surgical resection of glioma. METHODS: PubMed

Embase

CNKI

VIP

CBM and Wanfang Data were retrieved to collect the randomized controlled trials（RCT） of efficacy of fluorescein sodium injection-guided surgical resection of glioma. The retrieval time was from the establishment of the database to Apr. 2021. Meta-analysis was performed on RCT that met the quality standards

and RevMan 5.2 was used for statistical analysis. RESULTS: A total of 6 RCT with 333 patients were included. During the routine microsurgical resection of glioma in the observation group

the tumor tissue was stained by intravenous injection of sodium fluorescein injection

and the tumor boundary was judged according to the intensity of the fluorescent staining to perform tumor resection; the control group was resected by conventional microsurgery glioma. Meta-analysis showed that the total resection rate of glioma in the observation group was significantly higher than that in the control group（OR=5.51

95%CI=3.28-9.24

P<0.000 01）

the recurrence rate of glioma in the observation group after surgery was significantly lower than that in the control group（OR=0.30

95%CI=0.15-0.60

P=0.000 6）

with statistically significant differences. There were no significant differences in the average duration of surgery and average length of stay between two groups（P>0.05）. CONCLUSIONS: Compared with conventional microsurgery

fluorescein sodium injection-guided surgical resection of glioma has a higher total tumor resection rate and a lower postoperative tumor recurrence rate.