OBJECTIVE: To probe into the effects of Liangxue Huoxue recipe application on expression of serum cytokines and oxidative stress in patients with acute gouty arthritis of dampness-heat accumulation type. METHODS: Totally 112 patients with acute gouty arthritis admitted into the hospital from Jan. 2019 to Jun. 2021 were extracted to be divided into the observation group and the control group

with 56 cases in each group. The control group was treated with basic treatment regimen

while the observation group received the application of Liangxue Huoxue recipe application based on the basic treatment regimen. Both groups were treated for 7 d. Traditional Chinese medicine symptom scores

malondialdehyde（MDA）

3-nitrotyrosine modified protein（3-NT）

8-hydroxydeoxyguanosine（8-OHdG）

interleukin-6（IL-6）

tumor necrosis factor alpha（TNF-α）

uric acid（UA）

erythrocyte sedimentation rate（ESR）

and high-sensitivity C-reactive protein（hs-CRP） levels before and after treatment were compared between two groups. The clinical efficacy was observed. RESULTS: After treatment

the traditional Chinese medicine symptom scores such as joint pain

joint fever

joint swelling

joint movement

limb heaviness

thirst and short urine decreased significantly in two groups

while the observation group was significantly lower than the control group

the differences were statistically significant（P<0.05）. After treatment

the total effective rate of the observation group was 96.43%（54/56）

significantly higher than 85.71%（48/56） of the control group

the difference was statistically significant（P<0.05）. After treatment

the levels of IL-6

TNF-α

hs-CRP

UA and ESR were significantly lower in both groups than those before treatment

and the observation group was significantly lower than the control group

with statistically significant differences（P<0.05）. After treatment

the levels of MDA

3-NT and 8-OHDG in both groups were significantly lower than those before treatment

and the observation group was significantly lower than the control group

the differences were statistically significant（P<0.05）. CONCLUSIONS: The application of Liangxue Huoxue recipe application on patients with acute gouty arthritis of dampness-heat accumulation type can significantly improve patients’ clinical symptoms

reduce the expression of oxidative stress and regulate the expression level of inflammatory factors.