OBJECTIVE: To probe into the effects of renal artery embolization combined with Adrenal hydrazone tablets on coagulation function and renal function in patients with acute renal hemorrhage. METHODS: A total of 61 patients with acute renal hemorrhage admitted into the Ninth People’s Hospital Affiliated to Shanghai Jiaotong University School of Medicine from Sept. 2019 to Sept. 2021 were selected and divided into the single treatment group（n=30） and the combined treatment group（n=31） via random number table. The single treatment group was treated with renal artery embolization

while the combined treatment group received renal artery embolization combined with Adrenal hydrazone tablets. The renal function of two groups was compared. Plasma prothrombin time（PT）

activated partial thrombin time（APTT） and fibrinogen（FIB） levels were determined by immunoturbidimetry

and tumor necrosis factor α（TNF-α）

interleukin（IL）-1 and IL-22 levels were determined by enzyme-linked immunosorbent assay. The treatment effects and incidence of complications were observed. RESULTS: After treatment

the levels of hematocrit and hemoglobin in the combined treatment group were higher than those in the single treatment group

and the heart rate was lower than that in the single treatment group

with statistically significant differences（P<0.05）. After treatment

the levels of serum creatinine

24 h urine protein and blood urea nitrogen in the combined treatment group were lower than those in the single treatment group

the differences were statistically significant（P<0.05）. After treatment

PT and APTT in the combined treatment group were longer than those in the single treatment group

and the levels of FIB

TNF-α

IL-1 and IL-22 were lower than those in the single treatment group

the differences were statistically significant（P<0.05）. The total effective rate in the combined treatment group was 96.77%（30/31）

higher than 76.67%（23/30） in the single treatment group; the incidence of complications in the combined treatment group was 3.23%（1/31）

lower than 20.00%（6/30） in the single treatment group

the difference was statistically significant（P<0.05）. CONCLUSIONS: Renal arterial embolization combined with Adrenal hydrazone tablets in the treatment of acute renal hemorrhage can improve the renal function and the coagulation function

effectively regulate the inflammatory reaction

with remarkable therapeutic effects.