OBJECTIVE: To compare the status of medical orders with overdose oral drugs in central pharmacy of this hospital before and after the implementation of prescription pre-review system

and explore the role of the prescription pre-review system in the quality management of hospital prescriptions

so as to promote the clinical rational drug use. METHODS: Retrospective analysis was performed on medical orders with overdose oral drugs in central pharmacy of the hospital from Oct. 17

2017 to Oct. 16

2018（before the implementation of prescription pre-review system） and from Oct. 17

2018 to Sept. 16

2021（after the implementation of prescription pre-review system）. RESULTS: Before the implementation of prescription pre-review system

drugs involved in medical orders with overdose oral drugs in the central pharmacy of the hospital were mainly cardiovascular system drugs（20.0%

650/3 245）

and the department with the largest distribution of medical orders with overdose oral drugs was the respiratory and critical care medicine（23.6%

766/3 245）. After the implementation of prescription pre-review system

the incidence of medical orders with overdose oral drugs in central pharmacy of this hospital decreased from 20.0%（3 245/16 201） before the implementation to 7.7%（2 424/31 630）. CONCLUSIONS: There are many kinds of drugs in medical orders with overdose oral drugs in central pharmacy of this hospital

the departments are widely distributed

and the occurrence of overdose is relatively common. In order to standardize the dosage of medical orders

prescription pre-review system is used to set rules for the interception

which can significantly improve the occurrence of medical orders with overdose oral drugs and the status of clinical irrational drug use

improve the quality of medical orders with oral drugs for inpatients

and promote the rational drug use. Meanwhile

it is recommended that the hospital establish its own self-maintenance knowledge base and fine-tune the setting of drugs

which can not only prevent the issuance of irrational prescriptions/medical orders

but provide basis for the individualization medication according to the message prompt.