OBJECTIVE: To investigate the characteristics and regularities of adverse drug reactions（ADR） induced by linezolid in patients with drug-resistant tuberculosis

so as to promote the clinical rational drug use. METHODS: Retrospective analysis method was used

data of 84 drug-resistant tuberculosis patients with ADR induced by linezolid in Beijing Chest Hospital Affiliated to Capital Medical University from Dec. 2016 to Mar. 2021 were collected

and statistical analysis was performed on the data of gender

age

route of administration

usage and dosage

involved organs and（or） systems

clinical manifestations and blood concentration monitoring. RESULTS: Of the 84 patients with ADR

the male to female ratio was 1∶ 1.21. The average age was（65.6±10.7） years

and the proportion of patients >60 years was the highest（49 cases

58.33%）. The most ADR was induced by oral administration（67 cases

79.76%）. ADR induced by linezolid involved multiple organs and（or） systems

with 159 case-times of clinical manifestations

mainly blood system damage（55 case-times

34.59%）

followed by visual system damage（29 case-times

18.24%） and nervous system damage（27 case-times

16.98%）. Only 31 patients（36.90%） received blood concentration monitoring. CONCLUSIONS: Clinical manifestations of ADR induced by linezolid are diverse

and blood drug concentration monitoring can be performed during treatment. Especially in special patients

more attention should be paid to ADR monitoring to promote clinical rational drug use.