康复新液治疗糜烂性胃炎的网状Meta分析

刘慧; 夏伟; 陈大中; 曹林森; 李欣; 贺娟

doi:10.14009/j.issn.1672-2124.2022.03.024

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康复新液治疗糜烂性胃炎的网状Meta分析

用药评价 | 更新时间：2022-10-08

- 康复新液治疗糜烂性胃炎的网状Meta分析
- Kangfuxin Liquid in the Treatment of Erosive Gastritis: A Network Meta-Analysis
- 中国医院用药评价与分析 2022年22卷第3期页码：364-369
- 作者机构：
  
  1. 大理大学药学院
  2. 中国人民解放军联勤保障部队第九二〇医院药剂科
- 作者简介：
- 基金信息：
- DOI：10.14009/j.issn.1672-2124.2022.03.024
  中图分类号： R573.3
- 纸质出版日期：2022，
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刘慧, 夏伟, 陈大中, 等. 康复新液治疗糜烂性胃炎的网状Meta分析[J]. 中国医院用药评价与分析, 2022,22(3):364-369.

LIU Hui, XIA Wei, CHEN Dazhong, et al. Kangfuxin Liquid in the Treatment of Erosive Gastritis: A Network Meta-Analysis[J]. 2022,22(3):364-369.
刘慧, 夏伟, 陈大中, 等. 康复新液治疗糜烂性胃炎的网状Meta分析[J]. 中国医院用药评价与分析, 2022,22(3):364-369. DOI： 10.14009/j.issn.1672-2124.2022.03.024.

LIU Hui, XIA Wei, CHEN Dazhong, et al. Kangfuxin Liquid in the Treatment of Erosive Gastritis: A Network Meta-Analysis[J]. 2022,22(3):364-369. DOI： 10.14009/j.issn.1672-2124.2022.03.024.

摘要

目的：采用网状Meta分析方法，系统评价康复新液治疗糜烂性胃炎的疗效。方法：计算机检索PubMed、Embase、the Cochrane Library、中国知网、维普网、万方数据库和中国生物医学文献数据库，收集自建库至2021年3月康复新液治疗糜烂性胃炎的临床随机对照试验(对照组或研究组中治疗方案有采用康复新液单一治疗或联合治疗)

运用State 15.0和WinBUGS 1.4软件进行网状Meta分析。结果：最终纳入36项研究，包括3 918例患者，涉及10种治疗方案。网状Meta分析结果显示，射频+质子泵抑制剂+康复新液、氩离子凝固+质子泵抑制剂+康复新液、康复新液+饮食指导以及康复新液+质子泵抑制剂的疗效明显优于康复新液+胃黏膜保护剂、康复新液、射频+质子泵抑制剂、质子泵抑制剂+胃黏膜保护剂、质子泵抑制剂及胃黏膜保护剂，差异有统计学意义(P<0.05)。治疗有效性排序居第1位的治疗方案为射频+质子泵抑制剂+康复新液(SUCRA=93.7%

PrBest=58.2%)。安全性方面，质子泵抑制剂的不良反应病例数所占比例最高(占29.41%)

康复新液最低(占3.92%)。结论：康复新液与其他药物联合治疗糜烂性胃炎的效果优于其单药治疗，尤其与质子泵抑制剂联合应用可起到较好的治疗效果；在此基础上，增加物理治疗可进一步提高疗效，饮食指导可作为糜烂性胃炎的辅助治疗方案。不推荐使用胃黏膜保护剂的单药或联合治疗，治疗效果无明显提高，且存在一定的不良反应。

Abstract

OBJECTIVE: To systematically evaluate the efficacy of Kangfuxin liquid in the treatment of erosive gastritis based on network Meta-analysis. METHODS: PubMed

Embase

the Cochrane Library

CNKI

VIP

Wanfang Data and CBM databases were retrieved to collect the clinical randomized controlled trial of Kangfuxin liquid in the treatment of erosive gastritis（the control group or the study group were treated with Kangfuxin liquid

as monotherapy or combination therapy）

the retrieval time was from the establishment of the database to Mar. 2021. Network Meta-analysis was performed by using State 15.0 and WinBUGS 1.4 software. RESULTS: A total of 36 studies were enrolled

including 3 918 patients

with 10 kinds of treatment regimens. Network Meta-analysis showed that the efficacy of radiofrequency + proton pump inhibitor + Kangfuxin liquid

argon plasma coagulation + proton pump inhibitor + Kangfuxin liquid

Kangfuxin liquid + dietary guidance

and Kangfuxin liquid + proton pump inhibitor was significantly better than that of Kangfuxin liquid + gastric mucosal protective agent

Kangfuxin liquid

radiofrequency + proton pump inhibitor

proton pump inhibitor + gastric mucosal protective agent

proton pump inhibitor and gastric mucosal protective agent

the difference was statistically significant（P<0.05）. The treatment regimen took the lead in terms of efficacy was radiofrequency + proton pump inhibitor + Kangfuxin liquid（SUCRA=93.7%

PrBest=58.2%）. In terms of safety

proton pump inhibitor accounted for the highest proportion of adverse drug reactions（29.41%）

and Kangfuxin liquid was the lowest（3.92%）. CONCLUSIONS: The effect of Kangfuxin liquid combined with other drugs in the treatment of erosive gastritis is better than that of its monotherapy

especially combined with proton pump inhibitors. On this basis

physical therapy can further improve the curative effect

and dietary guidance can be used as an auxiliary treatment for erosive gastritis. It is not recommended to use single drug or combination therapy of gastric mucosal protective agent

the therapeutic effect is not significantly improved

and there are certain adverse reactions.

关键词

康复新液糜烂性胃炎有效性安全性网状Meta分析

Keywords

Kangfuxin liquidErosive gastritisEfficacySafetyNetwork Meta-analysis

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