OBJECTIVE: To systematically review the efficacy and safety of compound glycyrrhizin injection in adjuvant treatment of children with henoch-schonlein purpura（HSP） by Meta-analysis. METHODS: CNKI

Wanfang Data

VIP

PubMed

Embase

Web of Science

the Cochrane Library and other databases were retrieved to collect the randomized controlled trial of compound glycyrrhizin injection in adjuvant treatment of children with HSP（the control group received conventional treatment

and the treatment group was additionally given compound glycyrrhizin injection on the basis of the control group）. Strict inclusion and exclusion criteria were established to screen the included literature and evaluate the quality. Meta-analysis and publication bias analysis were performed by using RevMan 5.4.1 and Stata 16.0 statistical software

respectively. RESULTS: This study finally included 19 literature with a total of 1 405 children

including 714 children in the treatment group and 691 children in the control group. Meta-analysis showed that the clinical effective rate of compound glycyrrhizin injection combined with conventional treatment was significantly better than that of conventional treatment alone

with statistically significant differences（RR=1.25

95%CI=1.19-1.30

P<0.000 01）. Compared with the conventional treatment alone

compound glycyrrhizin injection combined with conventional treatment can shorten the disappearance time of HSP in children（MD=-3.29

95%CI=-4.81--1.77

P<0.000 1）

and the disappearance time of joint swelling and pain（MD=-2.00

95%CI=-2.71--1.30

P<0.000 01） and disappearance time of abdominal pain（MD=-1.64

95%CI=-2.33--0.95

P<0.000 01）

the differences were statistically significant. In terms of safety

there was no statistically significant difference in the incidence of adverse drug reactions between two groups（RR=1.56

95%CI=0.06-37.67

P=0.78）. CONCLUSIONS: Compound glycyrrhizin injection combined with conventional treatment can improve the clinical treatment effects of children with HSP

with mild adverse drug reactions and higher safety.