OBJECTIVE: To investigate the types and clinical characteristics of drug-induced hypomagnesemia

so as to remind the clinic to be alert to the occurrence of hypomagnesemia. METHODS: CNKI

Wanfang Data and PubMed were retrieved to collect the related literature of drug-induced hypomagnesemia

the retrieval time was from the establishment of the database to Mar. 2021. Types of drugs

clinical characteristics

treatment outcomes and related influencing factors that were likely to induce hypomagnesemia were summarized and analyzed. RESULTS: A total of 239 patients were enrolled in 20 case reports and 3 multi-case reports

there were 11 kinds of drugs in 5 categories with different pharmacological effects

including immunosuppressants（119 cases

49.79%）

antitumor drugs（102 cases

42.68%）

proton pump inhibitors（15 cases

6.28%）

antibiotics（2 cases

0.84%） and H

2

receptor antagonists（1 case

0.42%）. Among the 24 cases reported

the degree of hypomagnesemia was graded as grade 4 in 13 cases

grade 3 in 3 cases

grade 2 in 5 cases and grade 1 in 3 cases. The clinical manifestations of hypomagnesemia were mainly neuromuscular symptoms

altered consciousness with epilepsy and cardiovascular symptoms. CONCLUSIONS: Patients taking the above drugs that are likely to induce hypomagnesemia

especially the combination of multiple chronic diseases

long-term combined application of multiple drug therapy in middle-aged and elderly patients

clinicians should be alert to drug-induced hypomagnesemia

regularly provide monitoring for blood magnesium concentration and neurological symptoms to prevent the occurrence of hypomagnesemia. The treatment is targeted according to patients’ blood magnesium concentration level and clinical symptoms.