OBJECTIVE: To investigate the relevant situation of prophylactic medication of stress ulcer during perioperative period in China. METHODS: CNKI

Wanfang Data

VIP database and CBM were retrieved to collect the clinical studies related to prophylactic medication for stress ulcer during perioperative period. The retrieval time was from the establishment of different journals to Dec. 3 rd

2020. The relevant information was extracted and statistically analyzed for the included studies after reading the full text. RESULTS: A total of 36 studies were enrolled

including 22 624 surgical patients

of which totally 17 865 patients underwent stress ulcer prophylaxis. The rate of prophylactic medication for stress ulcer was 49.29%（4 539/9 208）in 18 studies. Twenty-nine studies evaluated stress ulcer prophylaxis for relevant indications

with an unindicated prophylaxis rate of 51.90%（6 758/13 020）. Nineteen studies evaluated the rationality of prophylactic medication for stress ulcer

and the irrational medication rate was 72.68%（8 329/11 460）. CONCLUSIONS: There is a large amount of over-prophylaxis in the prevention of stress ulcers in the perioperative period in China

with irrational drug use phenomenon.