OBJECTIVE: To probe into the short-term efficacy and possible mechanism of Danhong injection combined with conventional therapy in patients with chronic heart failure. METHODS: A total of 120 patients with chronic heart failure admitted into this hospital from Jun. 2018 to Jun. 2020 were extracted to be divided into the control group and the observation group via the random number table

with 60 cases in each group. The control group received conventional western medicine treatment

while the observation group was treated with Danhong injection on the basis of the control group. After treatment of 4 weeks

the short-term efficacy

total traditional Chinese medicine syndrome score

6-min walking test distance

and serum levels of high mobility group protein 1（HMGB1）

Toll-like receptor 4（TLR4） and nuclear factor κB（NF-κB） were compared between two groups. The occurrence of adverse drugs reactions was recorded. RESULTS: The efficacy classification in the observation group was better than that in the control group

and the total effective rate（100%

60/60） was significantly higher than that in the control group（93.33%

56/60）

the differences were statistically significant（P<0.05）. After treatment

the total traditional Chinese medicine syndrome scores in the observation group were significantly lower than those in the control group

the 6-min walking test distance was significantly longer than that in the control group

and the serum levels of HMGB1

TLR4 and NF-κB were significantly lower than those in the control group

with statistically significant difference（P<0.05）. During treatment

there were no obvious adverse drug reactions in two groups. CONCLUSIONS: Danhong injection can effectively optimize the therapeutic effects in patients with chronic heart failure

and the specific mechanism may be related to its regulation of HMGB1/TLR4/NF-κB pathway.