柴胡桂枝汤加减联合干扰素治疗带状疱疹后遗神经痛的临床疗效及对视觉模拟评分、睡眠质量的影响

徐雪怡; 黎顺成; 韦日铺; 杨进; 梁潇

doi:10.14009/j.issn.1672-2124.2022.02.015

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柴胡桂枝汤加减联合干扰素治疗带状疱疹后遗神经痛的临床疗效及对视觉模拟评分、睡眠质量的影响

论著 | 更新时间：2022-10-08

- 柴胡桂枝汤加减联合干扰素治疗带状疱疹后遗神经痛的临床疗效及对视觉模拟评分、睡眠质量的影响
- Clinical Efficacy of Chaihu Guizhi Decoction Combined with Interferon in the Treatment of Postherpetic Neuralgia and Its Effects on Visual Analogue Scale Score and Sleep Quality
- 中国医院用药评价与分析 2022年22卷第2期页码：185-187
- 作者机构：
  
  1. 海南省安宁医院医学康复科
  2. 广西中医药大学针推学院
- 作者简介：
- 基金信息：
  
  广西自然科学基金项目(No.2018GXNSFBA281198)
- DOI：10.14009/j.issn.1672-2124.2022.02.015
  中图分类号： R752.12
- 纸质出版日期：2022，
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徐雪怡, 黎顺成, 韦日铺, 等. 柴胡桂枝汤加减联合干扰素治疗带状疱疹后遗神经痛的临床疗效及对视觉模拟评分、睡眠质量的影响[J]. 中国医院用药评价与分析, 2022,22(2):185-187.

XU Xueyi, LI Shuncheng, WEI Ripu, et al. Clinical Efficacy of Chaihu Guizhi Decoction Combined with Interferon in the Treatment of Postherpetic Neuralgia and Its Effects on Visual Analogue Scale Score and Sleep Quality[J]. 2022,22(2):185-187.
徐雪怡, 黎顺成, 韦日铺, 等. 柴胡桂枝汤加减联合干扰素治疗带状疱疹后遗神经痛的临床疗效及对视觉模拟评分、睡眠质量的影响[J]. 中国医院用药评价与分析, 2022,22(2):185-187. DOI： 10.14009/j.issn.1672-2124.2022.02.015.

XU Xueyi, LI Shuncheng, WEI Ripu, et al. Clinical Efficacy of Chaihu Guizhi Decoction Combined with Interferon in the Treatment of Postherpetic Neuralgia and Its Effects on Visual Analogue Scale Score and Sleep Quality[J]. 2022,22(2):185-187. DOI： 10.14009/j.issn.1672-2124.2022.02.015.

摘要

目的：探讨柴胡桂枝汤加减联合干扰素治疗带状疱疹后遗神经痛的临床疗效及对视觉模拟评分（VAS）、睡眠质量的影响。方法：通过随机数字表法将2019年2月至2020年6月海南省安宁医院收治的110例带状疱疹后遗神经痛患者分为对照组和治疗组，每组55例。对照组患者给予干扰素治疗，治疗组患者在对照组的基础上联合柴胡桂枝汤加减治疗。观察两组患者治疗前后VAS评分、匹兹堡睡眠质量指数（PSQI）评分、皮肤病生活质量指数（DLQI）评分和中医证候评分，各血清指标[神经肽Y（NPY）、β-内啡肽（β-EP）、P物质（SP）和神经激肽-1（NK-1）]水平，并观察两组患者的临床疗效与不良反应发生情况。结果：与对照组的总有效率[85.45%（47/55）]

比较，治疗组患者的总有效率明显更高，为98.18%（54/55）

差异有统计学意义（χ

=5.930

P=0.015）。治疗后，两组患者VAS评分、PSQI评分、DLQI评分和中医证候评分均较治疗前明显降低，且治疗组患者上述评分明显低于对照组，差异均有统计学意义（P

0.05）。与治疗前相比，两组患者治疗后NPY、SP和NK-1水平均降低，β-EP水平升高；与对照组治疗后比较，治疗组患者治疗后NPY、SP和NK-1水平明显更低，β-EP水平明显更高，差异均有统计学意义（P

0.05）。治疗组患者的不良反应发生率为3.64%（2/55）

明显低于对照组的14.55%（8/55）

差异有统计学意义（χ

=3.960

P=0.047）。结论：针对带状疱疹后遗神经痛患者，采用柴胡桂枝汤加减联合干扰素治疗的疗效确切，不但能减轻患者的疼痛程度，还能提高睡眠质量和生活质量，改善症状，调节各类疼痛介质表达，且安全性较好。

Abstract

OBJECTIVE: To probe into the clinical efficacy of Chaihu Guizhi decoction combined with interferon in the treatment of postherpetic neuralgia and its effects on visual analogue scale（VAS） score and sleep quality. METHODS: Totally 110 patients with postherpetic neuralgia admitted into Hainan Provincial Anning Hospital from Feb. 2019 to Jun. 2020 were extracted to be divided into the control group and the treatment group via the random number table

with 55 cases in each group. The control group was treated with interferon

while the treatment group received Chaihu Guizhi decoction on the basis of the control group. The VAS score

Pittsburgh sleep quality index（PSQI）

Dermatology Life Quality Index（DLQI） and traditional Chinese medicine syndrome score

serum indicators [neuropeptide Y（NPY）

β-endorphins（β-EP）

substance P（SP） and neurokinin-1（NK-1）] before and after treatment were compared between two groups. Clinical efficacy and adverse drug reactions of two groups were analyzed. RESULTS: Compared with 85.45%（47/55） in the control group

the total effective rate in the treatment group was 98.18%（54/55）

the difference was statistically significant（χ~2=5.930

P=0.015）. After treatment

VAS score

PSQI score

DLQI score and TCM syndrome score in two groups were significantly lower than those before treatment

and the above scores in treatment group were significantly lower than those in control group

the differences were statistically significant（P<0.05）. After treatment

the levels of NPY

SP and NK-1 decreased and β-EP increased in two groups compared with before treatment. Compared with the control group after treatment

the levels of NPY

SP and NK-1 in the treatment group were significantly lower and the levels of β-EP were significantly higher after treatment

with statistically significant difference（P<0.05）. The incidence of adverse drug reactions in the treatment group was 3.64%（2/55）

significantly lower than 14.55%（8/55） in the control group

the difference was statistically significant（χ~2=3.960

P=0.047）. CONCLUSIONS: The efficacy of Chaihu Guizhi decoction combined with interferon in the treatment of postherpetic neuralgia is significant

which can reduce the degree of pain

improve the sleep quality and quality of life

improve the symptoms and regulate the expression of various pain mediators with higher safety.

关键词

柴胡桂枝汤干扰素带状疱疹后遗神经痛疼痛评分睡眠质量

Keywords

Chaihu Guizhi decoctionInterferonPostherpetic neuralgiaPain scoreSleep quality

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