温肺止咳平喘方联合沙丁胺醇雾化吸入对支气管哮喘患儿过敏原IgE、气道重塑和哮喘控制的影响

项李娥; 尚莉丽

doi:10.14009/j.issn.1672-2124.2022.02.014

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温肺止咳平喘方联合沙丁胺醇雾化吸入对支气管哮喘患儿过敏原IgE、气道重塑和哮喘控制的影响

论著 | 更新时间：2022-10-08

- 温肺止咳平喘方联合沙丁胺醇雾化吸入对支气管哮喘患儿过敏原IgE、气道重塑和哮喘控制的影响
- Effects of Wenfei Zhike Pingchuan Recipe Combined with Albuterol Nebulized Inhalation on Allergen IgE Level,Airway Remodeling and Asthma Control Level in Children with Bronchial Asthma
- 中国医院用药评价与分析 2022年22卷第2期页码：180-184
- 作者机构：
  
  安徽中医药大学第一附属医院儿科
- 作者简介：
- 基金信息：
- DOI：10.14009/j.issn.1672-2124.2022.02.014
  中图分类号： R725.6
- 纸质出版日期：2022，
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项李娥, 尚莉丽. 温肺止咳平喘方联合沙丁胺醇雾化吸入对支气管哮喘患儿过敏原IgE、气道重塑和哮喘控制的影响[J]. 中国医院用药评价与分析, 2022,22(2):180-184.

XIANG Li’e, SHANG Lili. Effects of Wenfei Zhike Pingchuan Recipe Combined with Albuterol Nebulized Inhalation on Allergen IgE Level,Airway Remodeling and Asthma Control Level in Children with Bronchial Asthma[J]. 2022,22(2):180-184.
项李娥, 尚莉丽. 温肺止咳平喘方联合沙丁胺醇雾化吸入对支气管哮喘患儿过敏原IgE、气道重塑和哮喘控制的影响[J]. 中国医院用药评价与分析, 2022,22(2):180-184. DOI： 10.14009/j.issn.1672-2124.2022.02.014.

XIANG Li’e, SHANG Lili. Effects of Wenfei Zhike Pingchuan Recipe Combined with Albuterol Nebulized Inhalation on Allergen IgE Level,Airway Remodeling and Asthma Control Level in Children with Bronchial Asthma[J]. 2022,22(2):180-184. DOI： 10.14009/j.issn.1672-2124.2022.02.014.

摘要

目的：探讨温肺止咳平喘方联合沙丁胺醇雾化吸入对支气管哮喘患儿过敏原免疫球蛋白E(IgE)水平、气道重塑和哮喘控制水平的影响。方法：选择2019年2月至2020年2月该院采用温肺止咳平喘方联合沙丁胺醇溶液雾化吸入治疗的52例支气管哮喘患儿作为观察组，另选同期该院采用沙丁胺醇溶液雾化吸入治疗的52例支气管哮喘患儿作为对照组。比较两组患儿的临床疗效，治疗前后的中医证候积分、过敏原IgE水平、气道重塑指标[气管内壁面积(Wai)、气道平滑肌面积(Wam)、支气管总管壁面积(Wat)]水平和哮喘控制测试(ACT)评分；采用随机行走模型评价两组患儿的过敏原IgE、气道重塑指标和哮喘控制水平。结果：两组患儿治疗前的鼻塞、咽痒、咳嗽和气急等中医证候积分，过敏原IgE、Wai、Wam、Wat水平和ACT评分比较，差异均无统计学意义(P>0.05)。两组患儿治疗后的各项中医证候积分、过敏原IgE水平和气道重塑指标水平较治疗前明显降低，ACT评分明显升高；其观察组患儿治疗后的总有效率、ACT评分明显高于对照组，各项中医证候积分、过敏原IgE水平和气道重塑指标水平明显低于对照组，上述差异均有统计学意义(P<0.05)。随机行走模型评价结果显示，观察组患儿的过敏原IgE、Wai、Wam、Wat水平和ACT评分改善情况优于对照组。结论：温肺止咳平喘方联合沙丁胺醇溶液雾化治疗能明显改善支气管哮喘患儿的过敏原IgE、气道重塑指标和哮喘控制水平，明显提高治疗总有效率。

Abstract

OBJECTIVE: To explore the effects of Wenfei Zhike Pingchuan recipe combined with albuterol nebulized inhalation on allergen IgE level

airway remodeling and asthma control level in children with bronchial asthma. METHODS: A total of 52 children with bronchial asthma who were treated with Wenfei Zhike Pingchuan recipe combined with albuterol nebulized inhalation in this hospital from Feb. 2019 to Feb. 2020 were selected as the observation group. And 52 children with bronchial asthma treated with albuterol nebulized inhalation were selected as the control group. Clinical efficacy

traditional Chinese medicine syndrome score

allergen IgE level

airway remodeling indicators [airway wall area（Wai）

airway smooth muscle area（Wam）

total bronchial wall area（Wat）] and asthma control test（ACT） score before and after treatment were compared between two groups. Allergen IgE

airway remodeling indicator and asthma control level were evaluated by random walking model. RESULTS: There was no statistically significant difference in traditional Chinese medicine syndromes scores such as nasal congestion

pharyngeal itching

cough and shortness of breath

allergen IgE

Wai

Wam and Wat levels and ACT scores between two groups before treatment（P>0.05）. After treatment

the traditional Chinese medicine syndromes scores

allergen IgE levels and airway remodeling indicators in two groups were significantly lower than those before treatment

while ACT scores were significantly higher. The total effective rate and ACT score of the observation group after treatment were significantly higher than those of the control group

and the traditional Chinese medicine syndromes scores

allergen IgE levels and airway remodeling indicators were significantly lower than those of the control group

the differences were statistically significant（P<0.05）. The evaluation results of random walking model showed that the improvement of allergen IgE

Wai

Wam

Wat and ACT scores in the observation group was better than that in the control group. CONCLUSIONS: Wenfei Zhike Pingchuan recipe combined with albuterol nebulized inhalation can significantly improve the allergen IgE

airway remodeling indicator and asthma control level in children with bronchial asthma

and significantly improve the total effective rate of treatment.

关键词

温肺止咳平喘方沙丁胺醇溶液支气管哮喘过敏原IgE气道重塑

Keywords

Wenfei Zhike Pingchuan recipeAlbuterol solutionBronchial asthmaAllergen IgEAirway remodeling

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