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上海市奉贤区中心医院骨科
纸质出版日期:2022,
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张辉, 薛锋. 肾上腺色腙片对髋关节置换术后止血消肿的效果研究[J]. 中国医院用药评价与分析, 2022,22(2):162-164.
ZHANG Hui, XUE Feng. Effects of Carbazochrome Tablets on Hemostasis and Swelling Reduction After Hip Replacement[J]. 2022,22(2):162-164.
张辉, 薛锋. 肾上腺色腙片对髋关节置换术后止血消肿的效果研究[J]. 中国医院用药评价与分析, 2022,22(2):162-164. DOI: 10.14009/j.issn.1672-2124.2022.02.009.
ZHANG Hui, XUE Feng. Effects of Carbazochrome Tablets on Hemostasis and Swelling Reduction After Hip Replacement[J]. 2022,22(2):162-164. DOI: 10.14009/j.issn.1672-2124.2022.02.009.
目的:探讨肾上腺色腙片对髋关节置换术后止血消肿的效果。方法:选取2020年1月至2021年1月该院收治的行髋关节置换术治疗的132例患者,按照随机数字表法分为对照组和肾上腺色腙片组,每组66例。对照组患者在髋关节置换术后使用凝血酶冻干粉干预,肾上腺色腙片组患者在髋关节置换术后使用肾上腺色腙片干预。观察两组患者失血、输血情况,D-二聚体、血红蛋白水平,肿胀、疼痛程度及术后不良事件发生情况。结果:与对照组相比,肾上腺色腙片组患者术后失血量、输血率均较低,差异均有统计学意义(P<0.05)。与对照组相比,肾上腺色腙片组患者术后1、7和14 d的D-二聚体水平明显降低,血红蛋白水平明显升高,差异均有统计学意义(P<0.05)。与对照组相比,肾上腺色腙片组患者肿胀程度较轻,疼痛评分较低,差异均有统计学意义(P<0.05)。与对照组[22.73%(15/66)]相比,肾上腺色腙片组患者术后不良事件发生率[6.06%(4/66)]较低,差异有统计学意义(P<0.05)。结论:髋关节置换术后应用肾上腺色腙片止血消肿的效果理想,可降低患者失血量,缓解患肢肿胀,减少不良事件的发生。
OBJECTIVE: To probe into the effects of carbazochrome tablets on hemostasis and swelling reduction after hip replacement. METHODS: Totally 132 patients undergoing hip replacement admitted into this hospital from Jan. 2020 to Jan. 2021 were extracted to be the control group and the carbazochrome tablets group via the random number table
with 66 cases in each group. The control group was treated with thrombin freeze-dried powder after hip replacement
while the carbazochrome tablets group received carbazochrome tablets after hip replacement. Blood loss
blood transfusion
D-dimer
hemoglobin level
swelling
pain and postoperative adverse events were observed in two groups. RESULTS: Compared with the control group
the postoperative blood loss and blood transfusion rate of the carbazochrome tablets were lower
the difference was statistically significant(P<0.05). Compared with the control group
D-dimer level decreased significantly and hemoglobin level increased significantly in the carbazochrome tablets group after surgery of 1
7 and 14 d
with statistically significant difference(P<0.05). Compared with the control group
the degree of swelling was lighter and the pain score was lower in the carbazochrome tablets group
the differences were statistically significant(P<0.05). Compared with the control group[22.73%(15/66)]
the incidence of postoperative adverse events in the carbazochrome tablets group was lower[6.06%(4/66)]
the difference was statistically significant(P<0.05). CONCLUSIONS: The application of carbazochrome tablets after hip replacement is ideal for hemostasis and swelling reduction
which can reduce the amount of blood loss in patients
relieve the swelling in the affected limb and reduce the occurrence of adverse events.
肾上腺色腙片髋关节置换术止血消肿
Carbazochrome tabletsHip replacementHemostasisSwelling reduction
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