OBJECTIVE: To probe into the clinical efficacy of omeprazole + α-lipoic acid

mosapride + α-lipoic acid in the treatment of gastroparesis in patients with type 2 diabetes mellitus and its effects on gastrointestinal hormones and oxidative stress. METHODS: Through prospective analysis

82 gastroparesis patients with type 2 diabetes mellitus admitted into this hospital from Oct. 2019 to Jun. 2020 were extracted to be divided into 41 cases in the observation group and 41 cases in the control group via the random number table. The control group was treated with mosapride + α-lipoic acid

while the observation group received omeprazole + α-lipoic acid. The clinical efficacy

gastrointestinal hormones and oxidative stress indicators before and after treatment in two groups were observed. RESULTS: The total effective rate in the observation group was 92.68%（38/41）

significantly higher than that in the control group 75.61%（31/41）

the difference was statistically significant（P<0.05）. Comparison of gastrin（GAS）

motilin（MTL） and somatostatin（SST） in time-point factors

time-point interaction factors and group factors in two groups showed statistically significant differences（P<0.05）. Glutathione peroxidase（GSH-Px）

superoxide dismutase（SOD） and reactive oxygen species（ROS） were compared between two groups in time-point factors and time-point interaction factors

the differences were statistically significant（P<0.05）. There were statistically significant differences in the above indicators between two groups before and after treatment（P<0.05）. After treatment

GAS

MTL and ROS in the observation group were significantly lower than those in the control group

while SST

GSH-Px and SOD were significantly higher than those in control group

with statistically significant differences（P<0.05）. CONCLUSIONS: The efficacy of omeprazole combined with α-lipoic acid in the treatment of gastroparesis in patients with type 2 diabetes is significantly higher than that of mosapride combined with α-lipoic acid

and the improvement of gastrointestinal hormones and oxidative stress in patients is better.