OBJECTIVE: To probe into the characteristics and regularities of the occurrence of allergic reactions induced by statins

so as to provide reference for clinical rational drug application. METHODS: Cases of allergic reactions induced by statins reported on the adverse dug reaction monitoring network in this hospital from Jan. 2015 to Mar. 2021 were selected

and literature related to allergic reactions induced by statins from Jan. 2000 to Mar. 2021 were retrieved from CNKI

Wanfang Data and VIP database

and the cases were statistically analyzed. RESULTS:There were 4 cases of allergic reactions induced by statins reported in this hospital

and 26 case reports（ 26 cases） of allergic reactions induced by statins were retrieved from the literature search

with a total of 30 cases; among them

19 cases（ 63. 33%） were male and 11 cases（ 36. 67%） were female; the ages of patients ranged from 32 to 85 years old

with a mean age of 61. 4 years old; the shortest time of allergic reactions was 5 minutes after oral administration

and the longest time was 6 months after continuous oral administration

of which 17 cases（ 56. 67%） occurred ≤3 d after drug administration; allergic reactions included skin allergy（ 19 cases）

allergic shock（ 3 cases）

angioneurotic edema（ 5 cases）

drug fever（ 2 cases）

and allergic asthma（ 1 case）; 5 cases（ 16. 67%） reported changing to other lipidregulating drugs as an alternative treatment regimen. CONCLUSIONS: Statins can lead to allergic reactions such as shock

angioneurotic edema and allergic asthma

so that attention to patient ’s medication monitoring during administration should be paid

especially at the initial stage of first administration; and adverse reactions should be reported promptly; for patients whose benefits from statins outweigh the disadvantages

alternative treatment regimens of allergic reactions should be clarified to provide reference for clinical medication.