OBJECTIVE: To promote the rational application of nonsteroidal anti-inflammatory drug（ NSAID） in patients after orthopedic surgery

so as to ensure medication safety. METHODS: Using prescription pre-review to build NSAID precise vetting database and conduct pre-review intervention

and a manual review on the application of NSAID in patients after fracture surgery in this hospital from Jan. to Jun. 2020（ before intervention） and from Jan. to Jun. 2021（ after intervention） was retrospectively conducted

so that the differences in irrational medication

pain scores and incidences of adverse drug reactions before and after the intervention were compared. RESULTS: After intervention

the irrational usage rate of NSAID had significantly decreased from 31. 61%（ 141/446） before intervention to 8. 17%（ 41/502）

with statistically significant difference（ P<0. 05）; the incidences of problems such as over-treatment of injections and inappropriate drug combination had significantly decreased compared with that of before intervention

with statistically significant difference（ P < 0. 01）; the incidence of adverse drug reactions had decreased from 2. 69%（ 12/446） before intervention to 0. 80%（ 4/502）

with statistically significant difference（ P < 0. 05）. The postoperative analgesic effects of the patients were comparable before and after intervention. CONCLUSIONS: The establishment and application of prescription pre-review database can effectively regulate the rational application of NSAID after surgery

ensure medication safety and promote the development of pharmacy services.