OBJECTIVE: To investigate the application of gabexate mesilate in inpatients from this hospital

so as to evaluate its rationality. METHODS: Medical records of 328 inpatients using gabexate mesilate in this hospital during2019-2020 were acquired

patients’ general information

hospitalization information and medication information were collected

the medication rationality was evaluated according to domestic and overseas guidelines and literature; totally 286 non-surgical patients diagnosed with acute pancreatitis were screened out

effects of different dosage regimens of gabexate mesylate on the treatment outcomes were preliminarily discussed. RESULTS: Among the 328 inpatients using gabexate mesilate

22 cases（ 6. 71%） were off-label and over-indication medication

all of them were surgical patients; 94 cases（ 28. 66%） were inappropriate solvents

93 cases used 0. 9% sodium chloride injection as the solvent and 1 case used10% dextrose injection as the solvent; 7 cases（ 2. 13%） were over-fast infusion speed

which was >2. 5 mg/（ kg·h）;161 cases（ 49. 09%） were combined application with ulinastatin. The combined application of ulinastatin and the different dosage regimens（ ≤5 d and >6 d） did not have significant effects on laboratory indicators

remission time of abdominal pain and length of hospital stay（ P>0. 05）. CONCLUSIONS: The clinical application of gabexate mesylate is still inadequate

and the clinic should pay close attention to promote its rational application.