OBJECTIVE: To probe into the therapeutic effect of Zhikang capsules for external use after anal fistula surgery. METHODS: Totally 120 patients underwent anal fistula surgery in this hospital from Oct. 2019 to Dec. 2020 were divided into control group and research group via random number table

with 60 cases in each group. The control group was given postoperative conventional therapy for the wound

while the research group was given Zhikang capsules based on the control group. The wound bleeding and granulation tissue growth scores at 1 week

2 weeks and 4 weeks after surgery

the healing time and overall efficacy

the positive expression rates of vascular endothelial growth factor（ VEGF） and vascular endothelial growth factor receptor 2（ VEGFR-2） in the wound margin tissue at 1 week and4 weeks after surgery

and the incidences of adverse drug reactions were compared between two groups. RESULTS:The postoperative wound bleeding and granulation tissue growth scores of both groups were significantly lower than those of before treatment; the wound bleeding and granulation tissue growth scores of the research group were significantly lower than those of the control group at 1 week

2 weeks and 4 weeks after surgery

with statistically significant differences（ P<0. 05）. The wound healing time was（ 25. 36 ± 2. 74） d in the research group

which was significantly shorter than（ 30. 28±3. 31） d in the control group

with statistically significant difference（ P<0. 05）. The total effective rate of research group was 93%（ 56/60）

which was significantly higher than that of the control group（ 80%

48/60）

with statistically significant difference（ P < 0. 05）. The positive expression rates of VEGF and VEGFR-2 in the wound margin tissue at 4 weeks after surgery were higher than those at 1 week after surgery in both groups

and the positive expression rates of VEGF and VEGFR-2 in the wound tissue at 4 weeks after surgery were significantly higher in the research group than in the control group

with statistically significant differences（ P<0. 05）.The incidence of adverse drug reactions were respectively 12%（ 7/60） and 7%（ 4/60） in research group and control group

the difference was not statistically significant（ P > 0. 05）. CONCLUSIONS: The external use of Zhikang capsules after anal fistula surgery can control the wound bleeding

promote the granulation tissue growth

shorten the wound healing time

enhance the clinical efficacy

also increase the positive expression rate of VEGF and VEGFR-2 in the wound margin tissue with higher safety.